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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 3 | Page No.: 301-305
DOI: 10.3923/ijp.2010.301.305
Hypoglycemic Activity of Red Kino Tree in Normal and Streptozotocin Induced Diabetic Rats
T. Radhika, P. Mahendar, A. Venkatesham, A.R.N. Reddy, Y. Narsimha Reddy, A. Sadanandam and T. Christopher

The aim of the present study was to evaluate the hypoglycemic activity of the methanolic extract from the bark of Red Kino Tree (RKT) (Fabaceae) at doses of 200 and 400 mg kg-1 (p.o.) in streptozotocin induced diabetic rats. Screening for the hypoglycemic activity was assessed on normoglycemic, streptozotocin treated hyperglycemic rats and in vitro study on glucose utilization by isolated rat hemidiaphragm. The serum biochemical parameters were also studied. The extract was found to possess significant hypoglycemic activity when compared with the reference standard glibenclamide. The in vitro study on glucose utilization by isolated rat hemidiaphragm suggests that the methanolic extract may have direct insulin like activity which enhances the peripheral utilization of glucose and also have extra pancreatic effect. The methanolic extract (400 mg kg-1) showed a significant decrease in triglycerides (TG) (p<0.01), Low Density Lipoprotein (LDL) (p<0.01), Very Low Density Lipoprotein (VLDL) (p<0.001) and a significant increase in High Density Lipoprotein (HDL) (p<0.05). The toxicity studies report safety usage of the plant extract. The present results clearly indicated that RKT, is potent for anti-diabetic effects in streptozotocin induced diabetic rats.
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