Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 3 | Page No.: 241-248
DOI: 10.3923/ijp.2010.241.248
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Protective Effects of Green tea (Camelia sinensis), Hypericum perforatum and Urtica dioica on Hepatic Injury and Lymphocyte DNA Damage Induced by Carbon Tetrachloride in Wistar Rats
M. Bitiren, D. Musa, A. Ozgonul, M. Ozaslan, A. Kocyigit, O. Sogut , Muhammet E. Guldur, I.H. Kilic, Ali Z. Karakilcik and M. Zerin

Abstract: The present study was planned to investigate the protective effects of herbal methanol extracts of Hypericum perforatum (HP) and Urtica dioica (UD) and herbal agueous extract of Camelia sinensis (CS)-containing antioxidants on carbon tetrachloride (CCl4)-induced hepatic injury and lymphocyte DNA damage. Adult male albino rats (n 50) were separated into five groups of ten each, as follows: control group; CCl4 group; CCl4+HP extract group; CCl4+UD extract group; CCl4+CS extract group. All extract groups were fed with 200 mg kg-1 extracts of HP, CS and UD, respectively once every alternate day for 7 weeks. CCl4 injections were applied to the CCl4 and extract groups at the dose of 0.4 mL kg-1. Malondialdehyde, total oxidant status and total antioxidative capacity levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl4 group and indicated increased oxidative stress. The DNA damages detected via commet assay were significantly higher than in the CCl4 group. Treatment by extracts of HP, CS or UD were significantly decreased this oxidative stress and ameliorated lymphocyte DNA damage. These results indicate that the herbal extracts of HP, UC and CS have beneficial effects on liver and lymphocyte DNA damage induced by CCl4 probably due to their antioxidant properties.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Ethanol-based Breadfruit Leaf (Artocarpus altilis) Extract as Hepatoprotective in Carbon Tetrachloride-induced Liver Injury
  •    Modulatory Effect of Aegle marmelos against Benzo (a) Pyrene B(a)P Induced Genotoxicity in Swiss Albino Mice
  •    A Systematic Review about Effects of Aerial Portions of Urtica dioica (Nettle) on Some Cardiovascular Risk Factors in Diabetes Mellitus
  •    The Study of Compositions and Antimicrobial Properties of Essential Oil of Origanum vulgare and Rosmarinus officinalis on Human Pathogens
How to cite this article:

M. Bitiren, D. Musa, A. Ozgonul, M. Ozaslan, A. Kocyigit, O. Sogut , Muhammet E. Guldur, I.H. Kilic, Ali Z. Karakilcik and M. Zerin, 2010. Protective Effects of Green tea (Camelia sinensis), Hypericum perforatum and Urtica dioica on Hepatic Injury and Lymphocyte DNA Damage Induced by Carbon Tetrachloride in Wistar Rats. International Journal of Pharmacology, 6: 241-248.

DOI: 10.3923/ijp.2010.241.248

URL: https://scialert.net/abstract/?doi=ijp.2010.241.248
 
COMMENT ON THIS PAPER
 
 
 

 
  Navigation
 
  Online First
  Current Issue
  Previous Issues
  Editorial Board
  Submit a Manuscript
  Guide to Authors
  Subscribe to E-alerts

  Indexed In
 
  ASCI-Database
  Asian Digital Library
  Chemical Abstract Services
  EMBASE
  Google Scholar
  ISI Web of Knowledge
  Science Citation Index (EXP)
  SCIMAGO
  Thomson ISI

       

       

Science Alert
Curve Bottom