Research Article

**Protective Effects of Green tea (Camelia sinensis), Hypericum perforatum and Urtica dioica on Hepatic Injury and Lymphocyte DNA Damage Induced by Carbon Tetrachloride in Wistar Rats**

M. Bitiren, D. Musa, A. Ozgonul, M. Ozaslan, A. Kocyigit, O. Sogut, Muhammet E. Guldur, I.H. Kilic, Ali Z. Karakilcik and M. Zerin

The present study was planned to investigate the protective effects of herbal methanol extracts of Hypericum perforatum (HP) and Urtica dioica (UD) and herbal agueous extract of Camelia sinensis (CS)-containing antioxidants on carbon tetrachloride (CCl₄)-induced hepatic injury and lymphocyte DNA damage. Adult male albino rats (n 50) were separated into five groups of ten each, as follows: control group; CCl₄ group; CCl₄+HP extract group; CCl₄+UD extract group; CCl₄+CS extract group. All extract groups were fed with 200 mg kg^-1 extracts of HP, CS and UD, respectively once every alternate day for 7 weeks. CCl₄ injections were applied to the CCl₄ and extract groups at the dose of 0.4 mL kg^-1. Malondialdehyde, total oxidant status and total antioxidative capacity levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl₄ group and indicated increased oxidative stress. The DNA damages detected via commet assay were significantly higher than in the CCl₄ group. Treatment by extracts of HP, CS or UD were significantly decreased this oxidative stress and ameliorated lymphocyte DNA damage. These results indicate that the herbal extracts of HP, UC and CS have beneficial effects on liver and lymphocyte DNA damage induced by CCl₄ probably due to their antioxidant properties.

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M. Bitiren, D. Musa, A. Ozgonul, M. Ozaslan, A. Kocyigit, O. Sogut, Muhammet E. Guldur, I.H. Kilic, Ali Z. Karakilcik and M. Zerin, 2010. Protective Effects of Green tea (Camelia sinensis), Hypericum perforatum and Urtica dioica on Hepatic Injury and Lymphocyte DNA Damage Induced by Carbon Tetrachloride in Wistar Rats. International Journal of Pharmacology, 6: 241-248.

DOI: 10.3923/ijp.2010.241.248

URL: https://scialert.net/abstract/?doi=ijp.2010.241.248

International Journal of Pharmacology

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Authors

M. Bitiren

D. Musa

A. Ozgonul

M. Ozaslan

A. Kocyigit

O. Sogut

Muhammet E. Guldur

I.H. Kilic

Ali Z. Karakilcik

M. Zerin

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Research Article

**Protective Effects of Green tea (Camelia sinensis), Hypericum perforatum and Urtica dioica on Hepatic Injury and Lymphocyte DNA Damage Induced by Carbon Tetrachloride in Wistar Rats**

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