Abstract:
By bioactivity-directed fractionation, three antioxidant
constituents have been characterized from Sargassum micracanthum collected
in Jeju Island, Korea. The potent antioxidant elucidated sargaquinoic
acid, sargachromenol and fucosterol by NMR and mass spectroscopic data.
The free radical scavenging activities of the sargaquinoic acid, sargachromenol
and fucosterol were investigated in relation to 1,1-diphenyl-2-picrylhydrazyl
(DPPH) and hydroxyl radicals using an Electron Spin Resonance (ESR) system.
The sargaquinoic acid and sargachromenol were found to scavenge DPPH (IC50,
49.3 and 100.2 μM). Therefore, these results resent sargaquinoic
acid and sargachromenol with a potent antioxidative activity that could
be useful in cosmetics, foods and pharmaceuticals.
Young Min Ham, Kil-Nam Kim, Wook Jae Lee, Nam Ho Lee and Chang-Gu Hyun, 2010. Chemical Constituents from Sargassum micracanthum and Antioxidant
Activity. International Journal of Pharmacology, 6: 147-151.
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