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International Journal of Pharmacology

Year: 2010 | Volume: 6 | Issue: 2 | Page No.: 129-133
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Authors

R.N.R. Anreddy

M. Porika

N.R. Yellu

R.K. Devarakonda

Keywords

Research Article

Hypoglycemic and Hypolipidemic Activities of Trianthema portulacastrum Linn. Plant in Normal and Alloxan Induced Diabetic Rats

R.N.R. Anreddy, M. Porika, N.R. Yellu and R.K. Devarakonda
The present study was designed to evaluate the hypoglycemic and hypolipidemic activity of methanol extract of Trianthema portulacastrum Linn. whole plant in normal and alloxan-induced diabetic rats. Alloxan was used to induce diabetes in rats and the blood glucose, lipid levels were estimated using commercial kits available in the market. The methanol extract of T. portulacastrum was administered for 7 days to normal and alloxan induced diabetes rats at a dose of 100, 200 and 300 mg kg-1. The extract produced significant reduction (p<0.001) in blood glucose at a doses of 100, 200 and 300 mg kg-1 in normal and diabetic rats. It also produced beneficial effects on the lipid profile in normal as well as alloxan induced diabetic rats at the end of the treatment period (7th day). The methanol extract of Trianthema portulacastrum produced a dose dependent hypoglycemic, antihyperglycemic and hypolipidemic activity in rats and were comparable with standard oral hypoglycemic agent, glibenclamide.
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