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International Journal of Pharmacology

Year: 2009 | Volume: 5 | Issue: 6 | Page No.: 381-383
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Authors

M.S. Shathele

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Research Article

Effect of Administration of Fungal Mycotoxin (Gliotoxin) on Clinical and Serobiochemical Parameters in Camels

M.S. Shathele
The main objective of this study was to determine the effect of administration of fungal mycotoxin (Gliotoxin) on clinical and serobiochemical parameters in camels. A bolus of 0.1 μg kg-1 b.wt. of gliotoxin was administered intravenously to camels. The treated camels were lethargic and decreased their appetite from day 3 onwards. The toxin administration decreased the protein and glucose concentration of serum. The increased activity of aspartate amino transferase, gamma glutamyl-transferase, sorbitol dehydrogenase and alkaline phosphatase due to mycotoxin administration was indicative of liver damage. High concentration of urea nitrogen and creatinine in treated animals was a characteristic of renal injury. In conclusion, the gliotoxin is acutely toxic to camels affecting liver and kidney function.
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