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International Journal of Pharmacology
  Year: 2009 | Volume: 5 | Issue: 4 | Page No.: 277-280
DOI: 10.3923/ijp.2009.277.280
 
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α-Glucosidase Inhibitor Activity of Terminalia Species

K. Anam, R.M. Widharna and D. Kusrini

Abstract:
Terminalia arjuna, Terminalia ballerica, Terminalia chebula, Terminalia catappa, Terminalia kaerbachii and Terminalia microcarpa leaves were tested for their α-glucosidase inhibitory activity in vitro. The α-glucosidase activity was determined by measuring the p-nitrophenol release from pNPG at 400 nm. Terminalia kaerbachii has the highest α-glucosidase inhibitor activity with IC50 value of 0.27±0.17 μg mL¯1 and is a promising antidiabetic herbal medicine candidate. However, most of the Terminalia species are also potential as antidiabetic medicine candidates as the IC50 values are approximately 5 μg mL-1, which is near the IC50 value of 1-deoxynojirimycin, the reference compound, except for Terminalia microcarpa, which has IC50 value of 25.15±0.04 μg mL-1 (above 21 μg mL-1). From the phytochemical screening, Terminalia kaerbacchi contains alkaloids, flavonoids and cathechic tannins, but does not contain saponin, quinon, steroid/terpenoids and gallic tannins. It is estimated that there is a correlation between α-glucosidase inhibitory activity and its phytochemical content.
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How to cite this article:

K. Anam, R.M. Widharna and D. Kusrini, 2009. α-Glucosidase Inhibitor Activity of Terminalia Species. International Journal of Pharmacology, 5: 277-280.

DOI: 10.3923/ijp.2009.277.280

URL: https://scialert.net/abstract/?doi=ijp.2009.277.280

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