α-Glucosidase Inhibitor Activity of Terminalia Species

Research Article

**α-Glucosidase Inhibitor Activity of Terminalia Species**

Terminalia arjuna, Terminalia ballerica, Terminalia chebula, Terminalia catappa, Terminalia kaerbachii and Terminalia microcarpa leaves were tested for their α-glucosidase inhibitory activity in vitro. The α-glucosidase activity was determined by measuring the p-nitrophenol release from pNPG at 400 nm. Terminalia kaerbachii has the highest α-glucosidase inhibitor activity with IC₅₀ value of 0.27±0.17 μg mL^¯1 and is a promising antidiabetic herbal medicine candidate. However, most of the Terminalia species are also potential as antidiabetic medicine candidates as the IC₅₀ values are approximately 5 μg mL^-1, which is near the IC₅₀ value of 1-deoxynojirimycin, the reference compound, except for Terminalia microcarpa, which has IC₅₀ value of 25.15±0.04 μg mL^-1 (above 21 μg mL^-1). From the phytochemical screening, Terminalia kaerbacchi contains alkaloids, flavonoids and cathechic tannins, but does not contain saponin, quinon, steroid/terpenoids and gallic tannins. It is estimated that there is a correlation between α-glucosidase inhibitory activity and its phytochemical content.

PDF Fulltext XML References Citation

How to cite this article

K. Anam, R.M. Widharna and D. Kusrini, 2009. α-Glucosidase Inhibitor Activity of Terminalia Species. International Journal of Pharmacology, 5: 277-280.

DOI: 10.3923/ijp.2009.277.280

URL: https://scialert.net/abstract/?doi=ijp.2009.277.280

International Journal of Pharmacology

Article Trend

Total views 359

Authors

K. Anam

R.M. Widharna

D. Kusrini

Keywords

Research Article

**α-Glucosidase Inhibitor Activity of Terminalia Species**

How to cite this article

Related Articles

Leave a Comment