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International Journal of Pharmacology
  Year: 2009 | Volume: 5 | Issue: 3 | Page No.: 236-239
DOI: 10.3923/ijp.2009.236.239
 
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Anti-Nociceptive Assets of Coral Associated Gastropod, Drupa margariticola

C. Chellaram and J.K. Patterson Edward

Abstract:
The extract of gastropod, Drupa margariticola tested for their analgesic assets using chemical (acetic acid) induced and hot plate method on Swiss mice model showed promising results. One hundred percent column purified extracts of the D. margariticola (25 and 100 mg kg -1 p.o.) exhibited significant (p<0.001) writhing inhibition of 65 and 78.57%, respectively against acetic acid induced abdominal constrictions. The result of hot plate study, in the difference between the mean reaction time and increased percentage of jump response of test animals in the treated groups, control and standard groups were statistically significant (p<0.001). At 30 min, the mean reaction time for extracts (50 mg kg -1 p.o.) group was 6.67 ±1 sec, when compared to control group (2.67 ±0.52 sec) and pentazocine treated groups (11.5 ±1.22 sec) for 100 mg kg -1 p.o. These facts suggest that the 100% acetone fraction of the D. margariticola was shown the strongest analgesic action. The important results obtained in present study were central and peripheral analgesic activities demonstrated by the inhibitory action on the acetic acid induced writhings and hot plate models. The hot plate method was found to be suitable in the evaluation of centrally acting analgesic action but not for peripherally acting analgesic action.
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How to cite this article:

C. Chellaram and J.K. Patterson Edward, 2009. Anti-Nociceptive Assets of Coral Associated Gastropod, Drupa margariticola. International Journal of Pharmacology, 5: 236-239.

DOI: 10.3923/ijp.2009.236.239

URL: https://scialert.net/abstract/?doi=ijp.2009.236.239

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