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International Journal of Pharmacology

Year: 2009 | Volume: 5 | Issue: 3 | Page No.: 215-221
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Authors

F.E. Uboh

M.I. Akpanabiatu

Y. Alozie

E.E. Edet

J.I. Ndem

P.E. Ebong

Keywords

Research Article

Comparative Effect of Vitamins A and E on Gasoline Vapours-Induced Haematotoxicity and Weight-Loss in Male Rats

F.E. Uboh, M.I. Akpanabiatu, Y. Alozie, E.E. Edet, J.I. Ndem and P.E. Ebong
Comparative effect of vitamins A and E on gasoline vapours haematotoxicity, growth-depression and weight-loss was assessed in male Wistar albino rats. The rats were exposed to gasoline vapours (17.8±2.6 cm3/h/m3/day), 6 h/day, 6 days/week for 20 weeks. Vitamins A (retinol) and E(α-tocopherol) at prophylactic dosage (400 and 200 IU/kg/day, respectively) were orally administered to the rats separately, in the last 2 weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), growth-rate and weight-gain in the rats exposed to the vapours were significantly lower (p<0.05) compared, respectively to the levels obtained for control rats. On the other hand, the levels of White Blood Cells (WBC) in the test rats were significantly higher (p<0.05) compared, respectively with the level obtained for male control rats. These observations indicate that exposure to gasoline vapours may cause haematotoxicity, growth-depression and weight-loss in male rats. However, administration of vitamins A and E was observed to produce a significant recovery (p<0.05) in haematotoxicity, growth-depression and weight-loss observed to be associated with exposure to gasoline vapours, although, the rats administered with vitamin E were noted to respond more favourably than those administered with vitamin A. This suggests that although retinol and α-tocopherol may be used to reverse or prevent haematotoxicity, growth-depression and weight-loss in subjects exposed to gasoline vapours, the reversal potency of α-tocopherol is higher than that of retinol.
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