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  1. International Journal of Pharmacology
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  3. 215-221
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International Journal of Pharmacology

Year: 2009 | Volume: 5 | Issue: 3 | Page No.: 215-221
DOI: 10.3923/ijp.2009.215.221

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Authors


F.E. Uboh

Country: Nigeria

M.I. Akpanabiatu

Country: Nigeria

Y. Alozie

Country: Nigeria

E.E. Edet

Country: Nigeria

J.I. Ndem

Country: Nigeria

P.E. Ebong

Country: Nigeria

Keywords


  • Gasoline vapours
  • haematotoxicity
  • retinol
Research Article

Comparative Effect of Vitamins A and E on Gasoline Vapours-Induced Haematotoxicity and Weight-Loss in Male Rats

F.E. Uboh, M.I. Akpanabiatu, Y. Alozie, E.E. Edet, J.I. Ndem and P.E. Ebong
Comparative effect of vitamins A and E on gasoline vapours haematotoxicity, growth-depression and weight-loss was assessed in male Wistar albino rats. The rats were exposed to gasoline vapours (17.8±2.6 cm3/h/m3/day), 6 h/day, 6 days/week for 20 weeks. Vitamins A (retinol) and E(α-tocopherol) at prophylactic dosage (400 and 200 IU/kg/day, respectively) were orally administered to the rats separately, in the last 2 weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), growth-rate and weight-gain in the rats exposed to the vapours were significantly lower (p<0.05) compared, respectively to the levels obtained for control rats. On the other hand, the levels of White Blood Cells (WBC) in the test rats were significantly higher (p<0.05) compared, respectively with the level obtained for male control rats. These observations indicate that exposure to gasoline vapours may cause haematotoxicity, growth-depression and weight-loss in male rats. However, administration of vitamins A and E was observed to produce a significant recovery (p<0.05) in haematotoxicity, growth-depression and weight-loss observed to be associated with exposure to gasoline vapours, although, the rats administered with vitamin E were noted to respond more favourably than those administered with vitamin A. This suggests that although retinol and α-tocopherol may be used to reverse or prevent haematotoxicity, growth-depression and weight-loss in subjects exposed to gasoline vapours, the reversal potency of α-tocopherol is higher than that of retinol.
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How to cite this article

F.E. Uboh, M.I. Akpanabiatu, Y. Alozie, E.E. Edet, J.I. Ndem and P.E. Ebong, 2009. Comparative Effect of Vitamins A and E on Gasoline Vapours-Induced Haematotoxicity and Weight-Loss in Male Rats. International Journal of Pharmacology, 5: 215-221.

DOI: 10.3923/ijp.2009.215.221

URL: https://scialert.net/abstract/?doi=ijp.2009.215.221

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