
	International Journal of Pharmacology
	Year: 2009 \| Volume: 5 \| Issue: 2 \| Page No.: 114-125 DOI: 10.3923/ijp.2009.114.125

Safety Evaluation of Long Term Treatment of Methanol Sub-Fraction of Seeds of Carica papaya as a Male Contraceptive with Particular Emphasis on Carcinogenicity in Albino Rats

S. Goyal, B. Manivannan, A.S. Ansari and N.K. Lohiya

Abstract: A preliminary study to evaluate if long term treatment of Methanol Sub-Fraction (MSF) of the seeds of Carica papaya as a male contraceptive would develop neoplastic lesions in vital organs was carried out in albino rats at 50, 250 and 500 mg kg^-1 b.wt. day^-1 for a period of 24 months, with a minimum dose being one therapeutic dose. Pre-terminal deaths, 45% in males and 48% in females, well within the acceptance limit, were reported to be age related and not treatment related, resulted due to general/respiratory/gastrointestinal/ urogenital disorders in both males and females of control and treated animals. Skin peeling, withering of fur leaving skin patches were observed in few of the animals after 18 months of treatment. Absence of spermatozoa in the cauda epididymis was evident in all the treated animals. No major structural changes compared to control were evident in the vital organs. Serum testosterone, serum electrolytes, tissue biochemical, hematology and clinical chemistry were comparable to those of control animals, suggesting no adverse effect of the test substance following long term treatment. The results provided evidence that the methanol sub-fraction of the seeds of Carica papaya does not lead any development of neoplastic lesion following life term treatment for 24 months in rats and is safe enough to be permitted for further trials as a male contraceptive.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	How to Cope with Dengue in Developing Countries Like Pakistan?

•	Observations on Chromosomal Aberrations Following the Administration of Methanol Sub-Fraction of Carica papaya Seeds for Contraception in Albino Rats and Rabbits

How to cite this article:

S. Goyal, B. Manivannan, A.S. Ansari and N.K. Lohiya, 2009. Safety Evaluation of Long Term Treatment of Methanol Sub-Fraction of Seeds of Carica papaya as a Male Contraceptive with Particular Emphasis on Carcinogenicity in Albino Rats. International Journal of Pharmacology, 5: 114-125.

DOI: 10.3923/ijp.2009.114.125

URL: https://scialert.net/abstract/?doi=ijp.2009.114.125

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services
		EMBASE
		Google Scholar
		ISI Web of Knowledge
		Science Citation Index (EXP)
		SCIMAGO
		Thomson ISI

Science Alert