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International Journal of Pharmacology

Year: 2008 | Volume: 4 | Issue: 1 | Page No.: 51-55
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Authors

Jude E. Okokon

Bassey S. Antia

Emem Umoh

Keywords

Research Article

Analgesic and Anti-Inflammatory Effects of Ethanolic Root Extract of Hippocratea africana

Jude E. Okokon, Bassey S. Antia and Emem Umoh
The ethanolic root extract of Hippocratea africana (200-600 mg kg-1) was evaluated for analgesic, anti-inflammatory and antipyretic properties. The extract dose dependently inhibited acetic acid-induced writhing, formalin-induced paw licking and thermally -induced pain in mice. The extract also inhibited fresh egg albumin, carrageenin and xylene-induced inflammation in mice. These inhibitions were statistically significant (p<0.05) when compared to control. The roots extracts was also found to reduce pyrexia in rats. The analgesic, anti-inflammatory and antipyretic activities of the extract may be related to its active constituents such as tannins, saponins, steroid and flavonoids.
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