Abstract:
This study was aimed to determine the histomorphometric
properties of hepatocytes mice (Balb/c) after using heroin. The factors
studied include the size of hepatocytes, nucleus diameter of hepatocytes,
size of binuclear hepatocytes and nucleus diameter of binuclear hepatocytes
of controls and treated experimental animals. A total of 30 male mice
were divided into three control and two treatment groups. At first, different
experimental groups were addicted to heroin with the dosage of 50 mg kg-1
IP for 3 days, twice daily and then were divided into two groups.
One of them received heroin with a dose of 5 mg kg-1 IP and
the other 5 mg mL-1 IP, twice daily for a period of 40 days.
The results showed that the heroin could exert a significant effect on
increasing the size of hepatocytes, size of binuclear hepatocytes, nucleus
diameter of binuclear hepatocytes and nucleus diameter of hepatocytes
in experimental groups.
S. Fazelipour, S.B. Kiaei, Z. Tootian and H. Dashtnavard, 2008. Histomorphometric Study of Hepatocytes of Mice after Using Heroin. International Journal of Pharmacology, 4: 496-499.
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