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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 6 | Page No.: 466-471
DOI: 10.3923/ijp.2008.466.471
Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats
M. Hassanpour Fard, S.L. Bodhankar and Madhumira Dikshit

Abstract:
The aim of present study was to investigate the cardioprotective effect of Lagenaria siceraria (LS) fruit powder against the cardiotoxicity of doxorubicin (Dox) in rats. Male wistar rats (250-300 g) were randomly divided into three groups. Group 1-was control (gum acacia 2%), group 2-Dox (10 mg kg-1), group 3-Dox+LS (200 mg kg-1 for 18 days). Dox (10 mg kg-1 i.v.) was administered in group 2 and 3 on day 16. After anesthetizing the animals on the 18th day, electrocardiogram (ECG) was recorded and blood was investigated for creatine kinase-MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) while determination of superoxide dismutase (SOD), reduced glutathione (GSH), lipid peroxidation (LPO) and histopathology was carried out for heart. Group 3 animals showed decreased QT and ST intervals (p<0.01 and p<0.05, respectively) and non significant increase in heart rate as compared to group 2. Significant decrease in serum CK-MB, AST (p<0.001) and LDH (p<0.05) of group 3 animals was observed as compared to group 2. There was significant increase in the level of GSH (p<0.05) and non significant increase in SOD, whereas lipid peroxidation (p<0.01) was inhibited in group 3 as compared to group 2. Histopathological study of LS treated group showed protection against myocardial toxicity induced by doxorubicin. Acute toxicity study showed that LS was safe at 5000 mg kg-1. It is concluded that Lagenaria siceraria possessed cardioprotective effect against doxorubicin induced cardiotoxicity in rats.
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How to cite this article:

M. Hassanpour Fard, S.L. Bodhankar and Madhumira Dikshit, 2008. Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats. International Journal of Pharmacology, 4: 466-471.

DOI: 10.3923/ijp.2008.466.471

URL: https://scialert.net/abstract/?doi=ijp.2008.466.471

 
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