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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 6 | Page No.: 443-451
DOI: 10.3923/ijp.2008.443.451
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Preclinical Evaluation of PM 701 in Experimental Animals

F. Khorshid

In this study, we addressed the toxicological effect of PM 701 on various animal species. Results showed that there was no mortality recorded to doses up to 10 g kg-1 body weights during the 4 weeks of observation. Function tests for Liver (SGOT-SGPT-Alk.Phos) and kidney (urea and creatinine) revealed that PM 701 have no hepatotoxic or nephrotoxic effects. No hematological toxicity was detected. Histological studies, showed no effect on gastric mucosa, no alteration in liver or kidney parenchyamatous architecture. Hepatocytes showed preserved cellular outline with no signs of necrosis. Few renal tubules showed degenerative changes. Splenic tissue showed activation and enlargement of germinal centers of white pulp lymph nodules indicating activation of immune defense without any effect on vital body organs. Therefore, compared to toxicity induced by well known chemotherapeutic agent, PM 701 could be considered safe as potentially anticancer agent with minimal or even negligible effects on vital organs such as liver and kidney and recommended to be subjected to clinical trial in human volunteers. PM 701 was categorized as practically non toxic.
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How to cite this article:

F. Khorshid , 2008. Preclinical Evaluation of PM 701 in Experimental Animals. International Journal of Pharmacology, 4: 443-451.

DOI: 10.3923/ijp.2008.443.451






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