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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 5 | Page No.: 382-387
DOI: 10.3923/ijp.2008.382.387
A Critical Period for Deleterious Effect of Prenatal Alcohol Exposure on Working Memory
S. Nourizad, M. Anvari, H. Hasani and M. Salami

Abstract:
The present study aimed to locate a critical period for ethanol-induced spatial task impairments in the animals exposed to alcohol during the fetal life. Two month old rats born from mothers treated with alcohol (5.7 g kg-1) during the 1st half (FH) and 2nd half (SH) and, the 1st (FQ), 2nd (SQ), 3d (TQ) and 4th quarter (FoQ) of gestational period were subjected to the working memory task. The experiments were carried out on an eight arm radial maze across 16 trials. The data presented here indicate that the animals in the FH group displayed a poor performance while those in the SH group had no problem in performing the maze task. Thus, it was concluded that the FH of pregnancy period is more sensitive to toxic effects of ethanol on the spatial task. Also, the FQ and SQ group`s performance indicated that the latter was significantly weak in solving the maze task. The animals related to the TQ and FoQ groups displayed a similar behavior with the control rats. Findings of this study demonstrated that drinking alcohol during pregnancy underlies cognitive phenomena in offspring. Noticeably, the second 5 days of the fetal life in the rats is more susceptible to deleterious effects of alcohol on the spatial tasks.
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How to cite this article:

S. Nourizad, M. Anvari, H. Hasani and M. Salami, 2008. A Critical Period for Deleterious Effect of Prenatal Alcohol Exposure on Working Memory. International Journal of Pharmacology, 4: 382-387.

DOI: 10.3923/ijp.2008.382.387

URL: https://scialert.net/abstract/?doi=ijp.2008.382.387

 
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