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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 4 | Page No.: 276-281
DOI: 10.3923/ijp.2008.276.281
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Effect of Garcinia kola Seed Extract on Female Reproductive Functions in Rats

B. Iranloye and B. Owokunle

The effects of G. kola seed extract on oestrous cycle, ovulation, implantation and pregnancy were studied in adult female rats with the aim of its possible use as female contraceptive. The three experimental groups were fed with G. kola seed extract (200 mg kg-1 body weight) (GKSE) and the control received distilled water once daily. Group 1 was fed with GKSE for three weeks and the estrous cycle monitored and number of ova released recorded. Group 2 consisted of pregnant rats and received GKSE from day one of pregnancy. Equal numbers of the rats were sacrificed on days six, eight and 19th of pregnancy. The total number of implants, resorption and viable foetuses were weighed, examined and recorded. Group 3 animals received GKSE daily for three weeks; half of them were sacrificed after three weeks and the others were allowed three weeks to recover from the effect of the extract. Histology of the ovary, uterus and fallopian tubes were done. The results showed that the oestrous cycle was altered with a significant reduction in the occurrence of estrous and metestrous phase. Ovulation was partially blocked (70% blockage). No significant difference between the number and weight of the implantation sites in both pregnant control rats and the GKSE rats. No significant difference in both the foetal number and weight on day 19 of pregnancy. GKSE made the uterine endometrial gland inactive, stopped maturation of the follicles, caused acute inflammation of the tubes but all the organs showed full recovery after administration of GKSE was stopped. GKSE may be use as a contraceptive with a possible advantage of reversibility.
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How to cite this article:

B. Iranloye and B. Owokunle, 2008. Effect of Garcinia kola Seed Extract on Female Reproductive Functions in Rats. International Journal of Pharmacology, 4: 276-281.

DOI: 10.3923/ijp.2008.276.281






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