Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 2 | Page No.: 135-139
DOI: 10.3923/ijp.2008.135.139
Biological Evaluation of Aqueous Herbal Extracts and Stirred Yoghurt Filtrate Mixture Against Alloxan-Induced Oxidative Stress and Diabetes in Rats
N.A. Al-Wabel, H.M. Mousa, O.H. Omer and A.M. Abdel-Salam

Abstract:
The aim of the present study was to investigate the biological effects of aqueous herbal extracts mixed with stirred yoghurt filtrate against alloxan-induced oxidative stress and diabetes in rats. Aqueous extracts of six medicinal plants: fenugreek, greater burdock, goat`s rue, colocynth, chicory and lupine were mixed with stirred yoghurt filtrate and used in the experiments. Blood glucose and alanine and aspartate aminotransferase (ALT and AST) activities were estimated before and after alloxan-induced oxidative stress and diabetes in rats. Obtained results showed that blood glucose levels in sera of treated rats fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture decreased with mean values of 135.0 ± 26.85 mg/100 mL serum compared with the treated rat fed on basal diet (positive control) with mean value of 237.66 ± 14.43 mg/100 mL serum. Data showed that ALT and AST activities in sera of treated rat fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture were nearest to the level of un-treated rats fed basal diet (negative control). The means values of ALT and AST level in treated group fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture were 57.33 ± 20 and 189.33 ± 48.85 compared with the positive control 90 ± 31.76 and 260.00 ± 57.27 and negative control 44.66 ± 9.5 and 180.66 ± 23.58 U L-1, respectively. Data concluded that mixture of medicinal plant extracts and stirred yoghurt filtrate may play a role in protection against alloxan-induced oxidative stress and diabetes in rat.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Renoprotective Effects of Reconstructed Composition of Trigonella foenum-graecum L. Seeds in Animal Model of Diabetic Nephropathy with and without Renal Ischemia Reperfusion in Rats
  •    Effect of Storage on Syneresis, pH, Lactobacillus acidophilus Count, Bifidobacterium bifidum Count of Aloe vera Fortified Probiotic Yoghurt
  •    Functional Foods: Hopefulness to Good Health
How to cite this article:

N.A. Al-Wabel, H.M. Mousa, O.H. Omer and A.M. Abdel-Salam, 2008. Biological Evaluation of Aqueous Herbal Extracts and Stirred Yoghurt Filtrate Mixture Against Alloxan-Induced Oxidative Stress and Diabetes in Rats. International Journal of Pharmacology, 4: 135-139.

DOI: 10.3923/ijp.2008.135.139

URL: https://scialert.net/abstract/?doi=ijp.2008.135.139

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom