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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 2 | Page No.: 114-119
DOI: 10.3923/ijp.2008.114.119
Protective Role of Tephrosia purpurea Ethanolic Seed Extract on Glycoprotein Components in Streptozotocin Induced Diabetic Rats
Pamu Pavana, Subramanian Sethupathy and S. Manoharan

Abstract:
The aim of the present study was to investigate the beneficial role of Tephrosia purpurea ethanolic seed extract on glycoprotein components in streptozotocin induced diabetic rats. Diabetes mellitus was induced in wistar rats by single intraperitoneal injection of streptozotocin (50 mg kg-1 b.wt.) dissolved in 0.1 M citrate buffer (pH 4.5) after overnight fasting for 12 h. Blood glucose and plasma insulin were measured and glycoprotein components (protein bound hexose, protein bound hexosamine, fucose and sialic acid) in plasma, erythrocyte membrane, liver and kidney were investigated in control and experimental animals in each group. Oral administration of TpESet at a dose of 300 mg kg-1 b.wt. to diabetic animals for 45 days revert back all the altered biochemical parameters in diabetic animals. The present study thus, indicates that TpESet has potent role in modifying altered glycoprotein components in streptozotocin induced diabetic rats.
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How to cite this article:

Pamu Pavana, Subramanian Sethupathy and S. Manoharan, 2008. Protective Role of Tephrosia purpurea Ethanolic Seed Extract on Glycoprotein Components in Streptozotocin Induced Diabetic Rats. International Journal of Pharmacology, 4: 114-119.

DOI: 10.3923/ijp.2008.114.119

URL: https://scialert.net/abstract/?doi=ijp.2008.114.119

COMMENTS
27 May, 2011
DR A K BRAHMACHARI:
The hematological profiles(TC, DC,Hct etc) are not incorporated in the study.Overlapping of several unidirectional parameters.No membrane electrophoresis has been done that could have revealed the actual picture in case of RBC membrane.The paper is very good and informative
 
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