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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 1 | Page No.: 74-79
DOI: 10.3923/ijp.2007.74.79
 
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Antihepatotoxic Activity of Xylopia phloiodora Extracts on Some Experimental Models of Liver Injury in Rats

Paul F. Moundipa, Silvere Ngouela, Georges Alain Tchamba, Nico F. Njayou, Pascal D.D. Chuisseu, Fabien Zelefack and Etienne Tsamo

Abstract:
The antihepatotoxic effects of Xylopia phloiodora extracts were evaluated in experimental models of liver injury in rats induced by CCl4 or paracetamol. Crude extract (CE), ether extract (EE) and essential oils from stem bark or leaves were tested. Hepatic function was accessed by measuring serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in rats. Liver malondialdehyde (MDA) and reduced glutathione were also measured in control and treated rats. X. phloiodora leaves (CE) and stem bark (CE) extracts showed hepatoprotective activities at doses equivalent to 2.5 g of plant/kg, since serum levels of ALT and AST in rats given the extracts were significantly low (p<0.05 and p<0.01, respectively) when compared to control CCl4-injured rats. Further studies were carried on the CE from stem bark of X. phloiodora which showed the highest level of protection against hepatitis. Further studies of the crude extract showed highest antihepatotoxic activity with the ether precipitate (PE) which was effective at 100mg/kg for hepatocurative activity in CCl4-injured rats. In experiments comparing the PE (100 mg kg-1) to a reference antihepatotoxic substance (silymarin) the PE exhibited a 71 and 80% hepatoprotection compared to the 80 and 90% one exhibited by silymarin in CCl4-and paracetamol-injured rats respectively. This study demonstrated that ether precipitate of Xylopia phloiodora was effective in protecting the liver from toxic hepatitis.
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How to cite this article:

Paul F. Moundipa, Silvere Ngouela, Georges Alain Tchamba, Nico F. Njayou, Pascal D.D. Chuisseu, Fabien Zelefack and Etienne Tsamo, 2007. Antihepatotoxic Activity of Xylopia phloiodora Extracts on Some Experimental Models of Liver Injury in Rats. International Journal of Pharmacology, 3: 74-79.

DOI: 10.3923/ijp.2007.74.79

URL: https://scialert.net/abstract/?doi=ijp.2007.74.79

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