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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 1 | Page No.: 61-67
DOI: 10.3923/ijp.2007.61.67
The Spasmogenic and Spasmolytic Activities of Lavandula stoechas are Mediated Through Muscarinic Receptor Stimulation and Calcium Channel Blockade
Qaiser Jabeen, Nauman Aziz, Zeeshan Afzal and Anwarul Hassan Gilani

Abstract:
The crude extract of Lavandula stoechas (Ls.Cr) and its fractions were studied in vitro for the possible presence of spasmogenic and spasmolytic constituents to rationalize some of the traditional uses. Ls.Cr (1-10 mg mL-1) caused atropine-sensitive spasmogenic effect in guinea pig ileum. In spontaneously contracting rabbit jejunum, Ls.Cr (0.03-1 mg mL-1) caused a transient spasmogenicity followed by relaxation at higher doses. Ls.Cr also relaxed high K+- induced contractions at the similar dose range (0.03-1 mg mL-1), which suggests that the spasmolytic effect is mediated through Calcium Channel Blockade (CCB). The CCB effect was confirmed when pretreatment of the tissue with Ls.Cr produced a dose-dependent shift in the Ca++ dose-response curves to the right, similar to that produced by verapamil. Activity-directed fractionation revealed that the spasmolytic effect is concentrated in the petroleum fraction while the spasmogenic effect is more evident in the aqueous fraction. These data indicate the presence of both spasmogenic and spasmolytic components mediated through muscarinic receptor activation and calcium channel blockade, respectively. This study also resolves the controversial results obtained from earlier studies and may explain some of its medicinal uses in gut disorders, like constipation and spasm.
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How to cite this article:

Qaiser Jabeen, Nauman Aziz, Zeeshan Afzal and Anwarul Hassan Gilani, 2007. The Spasmogenic and Spasmolytic Activities of Lavandula stoechas are Mediated Through Muscarinic Receptor Stimulation and Calcium Channel Blockade. International Journal of Pharmacology, 3: 61-67.

DOI: 10.3923/ijp.2007.61.67

URL: https://scialert.net/abstract/?doi=ijp.2007.61.67

 
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