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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 6 | Page No.: 492-498
DOI: 10.3923/ijp.2007.492.498
 
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Effect of Calcium Chloride on Cyclophosphamide-Induced Genotoxic and Biochemical Changes in Swiss Albino Mice

A.M. Aleisa

Abstract:
The present study was conducted to investigate the effect of calcium chloride on cyclophosphamide (CP)-induced genotoxicity and biochemical changes. The experimental protocol included oral treatment of mice with different doses (50, 100 and 200 mg/kg/day) of calcium chloride for 7 days. Some mice in each group were injected i.p. with CP (100 mg kg-1). In each case animals were killed, 24 h after the last treatment and femurs was excised for cytological studies by micronucleus test. Liver from each mouse was excised and preserved at -70°C for estimation of proteins, nucleic acids, malondialdehyde (MDA) and Nonprotein Sulphydryl (NP-SH) groups. The results obtained revealed that pretreatment with calcium chloride (i) reduced the CP-induced increase in the frequency of micronuclei without any alteration in its cytotoxicity and (ii) protected against the CP-induced increase of MDA and decrease of DNA and NP-SH. The exact mechanism of action is not known, however; the inhibition of CP-induced clastogenicity and lipid peroxidation by calcium chloride may be attributed to the antioxidant action of the latter. Present results demonstrate that calcium chloride might be useful to avert secondary tumor risk by decreasing the accumulation of free radicals and inhibition of mutagenicity.
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How to cite this article:

A.M. Aleisa , 2007. Effect of Calcium Chloride on Cyclophosphamide-Induced Genotoxic and Biochemical Changes in Swiss Albino Mice . International Journal of Pharmacology, 3: 492-498.

DOI: 10.3923/ijp.2007.492.498

URL: https://scialert.net/abstract/?doi=ijp.2007.492.498

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