Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 1 | Page No.: 48-54
DOI: 10.3923/ijp.2007.48.54
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Restorative Effect of Asparagus racemosus on Age Related Oxidative Damage in Heart Lysosome of Aged Rats

Sivanandham Velavan and Vava Mohaideen Hazeena Begum

Abstract:
In the present study, we have evaluated the salubrious role of asparagus racemosus root extract (ARRE) on accumulation of oxidative damage products such malondialdehyde (MDA), protein carbonyls (PCO), lysosomal marker enzymes acid phosphatase and cathepsin D activity, aging marker lipofuscin and membrane bound H+ ATPase activity in heart lysosome of aged rats. Male albino rats of Wistar strain were divided into four groups: Group 1, young control rats; Group 2, young rats treated with ARRE (500 mg kg-1 b.wt.) for four weeks; Group 3, aged control rats; Group 4, aged rats supplemented with ARRE (500 mg kg-1 b.wt.) for four weeks. Present results, thus, revealed that ARRE has inhibiting effect on the accumulation of age-related oxidative damages and restored the enzyme activity and decreased the lipofuscin content in heart lysosomes. This restorative activity of ARRE mainly attributed to the presence of enriched therapeutic phytochemical constituents, which act synergistically to alleviate the indices of oxidative stress, associated with aging.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Cytotoxicity, Analgesic and Antidiarrhoeal Activities of Asparagus racemosus
  •    Immunomodulatory Effect of Withania somnifera, Asparagus racemosus and Picrorhiza kurroa Roots
  •    Phytochemical Investigation and Evaluation of Antibacterial and Antioxidant Potentials of Asparagus racemosus
How to cite this article:

Sivanandham Velavan and Vava Mohaideen Hazeena Begum, 2007. Restorative Effect of Asparagus racemosus on Age Related Oxidative Damage in Heart Lysosome of Aged Rats. International Journal of Pharmacology, 3: 48-54.

DOI: 10.3923/ijp.2007.48.54

URL: https://scialert.net/abstract/?doi=ijp.2007.48.54

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom