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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 4 | Page No.: 367-370
DOI: 10.3923/ijp.2007.367.370
Effects of Ephedrine on the Onset of Neuromuscular Block and Hemodynamic Responses Following Priming by Atracurium
Sussan Soltanimohammadi and Mirsadegh Seyedi

In a double blinded study, seventy ASA I and II patients, undergoing elective surgery under general anesthesia were randomized into two equal groups. In both groups, 2 μg kg-1 fentanyl was injected as premedication. Anesthesia was induced by 1.5 mg kg-1 of propofol and subsequently was maintained with a propofol infusion at a rate of 8 mg kg-1 h-1. After control-TOF obtained and recorded by accelerometer, priming dose of atracurium 0.05 mg kg-1 was injected intravenously and 2.5 min later, intubating dose of atracurium 0.5 mg kg-1 with 140 μg kg-1 ephedrine in study group or equal volume of the saline in control group were injected. When TOF ratio became zero, patients tracheas were intubated. Variables were noted as: heart rate and blood pressure as baseline, 1, 3, 5 min after induction and one minute after intubation and onset time of atracurium when TOF ratio became zero. Data were analyzed by Independent sample t-test, Chi-square, Mann-Whitney U-test and Repeated measures ANOVA. p<0.05 was considered statistically significant. Onset time of atracurium for intubation was shorter in ephedrine group (p = 0.0001). The baseline values of Mean Arterial Pressure (MAP) and Heart Rate (HR) did not differ between the two groups. HR and MAP at first and third minutes after induction were lower than baseline in each group (p = 0.0001). There was significant statistical (not clinical) difference in mean HRs between the two groups (p = 0.003).The difference of mean MAPs was not statistically significant between the two groups (p = 0.213). Ephedrine, accelerated the onset time of atracurium in priming technique, with minimal hemodynamic effects.
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How to cite this article:

Sussan Soltanimohammadi and Mirsadegh Seyedi , 2007. Effects of Ephedrine on the Onset of Neuromuscular Block and Hemodynamic Responses Following Priming by Atracurium . International Journal of Pharmacology, 3: 367-370.

DOI: 10.3923/ijp.2007.367.370






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