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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 4 | Page No.: 362-366
DOI: 10.3923/ijp.2007.362.366
Hepatoprotective Effect of the Ethanolic Extract of Urtica parviflora Roxb. in CCl4 Treated Rats
Prasanna Kumar Kar , Lilakanta Nath , Suvakanta Dash , L. Sutharson and Bhagabat Nanda

Abstract:
The ethanolic extract of leaves of Urtica parviflora (EEUP) was evaluated for the hepato protective effect in carbon tetrachloride (CCl4) induced hepatotoxicity in rats to prove its ethnomedicinal claim by the hill people of Sikkim. Hepatotoxicity was induced in Swiss Albino male rats of Sprague Dawley strain by subcutaneous injection of carbon tetrachloride at the dose of 1 mL kg-1 body weight. The hepatoprotective activity was evaluated by the assay of liver function biochemical parameters such as aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP), total bilirubin, serum protein and by study of histopathology of the livers. The toxic effect of carbon tetrachloride was controlled significantly by the EEUP at 250, 500 and 700 mg kg-1 p.o. (p<0.05) as compared to the CCl4 treated animals by restoration of the levels of serum bilirubin, proteins and hepato protective enzymes. Histopathological studies revealed that the centrolobular necrosis induced by CCl4 was recovered to normal state by EEUP in a dose dependent manner. The study confirms the possible hepatoprotective potentiality of the ethanolic extract of leaves of Urtica parviflora which had been collected from Sikkim. Studies are under process to isolate and characterize the bioactive component present in the plant as well as to establish the mechanism of action underlying for its hepatoprotective potentiality.
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How to cite this article:

Prasanna Kumar Kar , Lilakanta Nath , Suvakanta Dash , L. Sutharson and Bhagabat Nanda , 2007. Hepatoprotective Effect of the Ethanolic Extract of Urtica parviflora Roxb. in CCl4 Treated Rats. International Journal of Pharmacology, 3: 362-366.

DOI: 10.3923/ijp.2007.362.366

URL: https://scialert.net/abstract/?doi=ijp.2007.362.366

 
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