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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 4 | Page No.: 327-333
DOI: 10.3923/ijp.2007.327.333
Screening of Alafia multiflora for Antibacterial, Antiradical Activity and LD50 Investigation
David E. Tsala , Dimo Theophile , Ngondi Judith , Nnanga Nga , Penlap B. Veronique , Boda Maurice and Njifutie Njikam

Abstract:
The purpose of this investigation deals with the antibacterial, antiradical activities and the toxicity (LD50 and haematological parameters) of Alafia multiflora stem barks. A. multiflora is a medicinal plant known for its curative effects on ulcerous wounds. Antibacterial activities of crude extracts were evaluated against E. coli, S. aureus, E. agglomerans, P. aeruginosa, P. vulgaris, K. Pneumoniae and the inhibitory zones as well as the Minimum Inhibition Concentrations (MIC) determined. Antiradical activity and total phenolic compounds of the extracts were evaluated. Methanol, methylene-chloride/methanol and aqueous extracts inhibited the growth of all the test microorganisms with MIC values ranged from 2.5 to 40 mg mL-1. The best antiradical activity was obtained at 0.25 mg mL-1. These results suggest that A. multiflora possess antibacterial and antiradical constituents. Aqueous and the methanol extracts administered in single oral doses of 0, 2.5, 5, 7.5 and 10 g kg-1 to groups of 10 rats (5 males, 5 females) yielded no mortality after 7 days observation. The LD50 values of the tested extracts were found to be above 5000 mg kg-1, indicating that A. multiflora is rather poorly toxic. A significant increase of platelet count was observed in animals treated with aqueous and methanol extracts at 5 to 10 g kg-1.
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How to cite this article:

David E. Tsala , Dimo Theophile , Ngondi Judith , Nnanga Nga , Penlap B. Veronique , Boda Maurice and Njifutie Njikam , 2007. Screening of Alafia multiflora for Antibacterial, Antiradical Activity and LD50 Investigation. International Journal of Pharmacology, 3: 327-333.

DOI: 10.3923/ijp.2007.327.333

URL: https://scialert.net/abstract/?doi=ijp.2007.327.333

 
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