Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 4 | Page No.: 302-310
DOI: 10.3923/ijp.2007.302.310
Interaction of Artemisinin Based Antimalarial Drugs with Hemin in Water-DMSO Mixture
P.T. Mpiana, B.K. Mavakala and Yu Zhi-Wu

Abstract:
The interaction of hemin with artemisinin, artesunate and dihydroartemisinin was investigated by UV-Visible Spectroscopy at pH 9 and High Performance Liquid Chromatography/Diode Array Detector/Mass Spectrometry (HPLC/DAD/MS) for their reactivity with hemin. It has been showed that artesunate and dihydroartemisinin interacted more strongly with Fe (III) PPIX that artemisinin did. The reported results showed too that hemin and endoperoxide lactone derived antimalarials slowly react to give rise to several stereoisomers supramolecular adducts (three for artesunate, seven for artemisinin and eight isomers for dihydroartemisinin) while in contrast, only heme (Fe2) was found to react with artemisinin based drugs in previous studies. Based on this result, our work confirmed the mechanism in which the artemisinin derivates approach hemin by pointing O1 at the endoperoxide linkage toward iron center, a mechanism that is controlled by steric hindrance. After that C3-C4 bond is cleaved to give rise carbon radical at C4 as predicted by automated calculation of docking of artemisinin to heme.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Induction and Uncoupling of Rat Liver Mitochondria by Oral Administered Coartemether
  •    Effect of Malarial Treatments on Biochemical Parameters and Plasma pH of Mice Infected with Plasmodium berghei
  •    Some Histological Observations and Microstructural Changes in the Nissl Substances in the Cerebellar Cortex of Adult Wistar Rats following Artesunate Administration
How to cite this article:

P.T. Mpiana, B.K. Mavakala and Yu Zhi-Wu , 2007. Interaction of Artemisinin Based Antimalarial Drugs with Hemin in Water-DMSO Mixture. International Journal of Pharmacology, 3: 302-310.

DOI: 10.3923/ijp.2007.302.310

URL: https://scialert.net/abstract/?doi=ijp.2007.302.310

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom