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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 3 | Page No.: 210-218
DOI: 10.3923/ijp.2007.210.218
Antiinflammatory and Antinociceptive Effects of Galega purpurea Root
M. Gupta , U.K. Mazumdar and P. Gomathi

Abstract:
The present study was designed to investigate anti-inflammatory and antinociceptive activities of Galega purpurea root. In this study both acute and chronic inflammation models were used to evaluate the anti-inflammatory activity of the extract and four different animal models were employed to investigate the antinociceptive activity of the extract. In acute model carrageenan, dextran, histamine and serotonin models were used to induce inflammation in rat hind paw and cotton pellet-induced granuloma method was used for chronic inflammation model. Acetic acid-induced writhing, method hot plate method, tail flick response and tail immersion methods were used to evaluate the antinociceptive effect of the extract. The methanol extract of Galega purpurea root exhibited significant, dose-dependent activity on the tested experimental animal models. Also the extract significantly reduced the acetic acid-induced abdominal contractions and the increased reaction time of mice in hot plate method, tail flick response and tail immersion method. This study has shown that the methanol extract from the roots of Galega purpurea does possess significant antiinflammatory and antinociceptive activity in laboratory animals at the doses tested and the results were comparable to those observed for the standard drugs indomethacin, acetyl salicylic acid and morphine.
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How to cite this article:

M. Gupta , U.K. Mazumdar and P. Gomathi , 2007. Antiinflammatory and Antinociceptive Effects of Galega purpurea Root. International Journal of Pharmacology, 3: 210-218.

DOI: 10.3923/ijp.2007.210.218

URL: https://scialert.net/abstract/?doi=ijp.2007.210.218

 
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