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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 2 | Page No.: 175-178
DOI: 10.3923/ijp.2007.175.178
Effect of a Polyherbal Formulation (Diarun plus) on the Glycemic Status Modified by Physiological Means in Non-diabetic Mice and Rats
G. Senthilvel, Anoop Austin, M. Jegadeesan, P. Thirugnanasambantham, N. Narayanan and S. Viswanathan

Abstract:
Diarun plus a polyherbal formulation containing herbal ingredients of folkloric Antidiabetic effect, was investigated for its effect on glycemic status in rats and mice. In contrast to conventional chemical induced diabetic animal models, changes in glycemic states were induced by physiological maneuvers. Results revealed that in euglycemic animals Diarun plus elicited little change (-10 to +10%) insignificantly. In food deprivation/swim exercise induced hypoglycemia, Diarun plus reduced the degree of hypoglycemia in both rats and mice (From 38 to 27% in rats and 45 to 32% in mice). Similarly, the marked hyperglycemia induced by dextrose (70% in rats and 95% in mice) was reduced markedly to 8 and 25% , respectively. The findings of the present study suggests that the ingredients of Diarun plus have the unique property of maintaining near euglycemic state irrespective of the altered glycemic state and that have no significant effect in euglycemic condition.
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How to cite this article:

G. Senthilvel, Anoop Austin, M. Jegadeesan, P. Thirugnanasambantham, N. Narayanan and S. Viswanathan, 2007. Effect of a Polyherbal Formulation (Diarun plus) on the Glycemic Status Modified by Physiological Means in Non-diabetic Mice and Rats. International Journal of Pharmacology, 3: 175-178.

DOI: 10.3923/ijp.2007.175.178

URL: https://scialert.net/abstract/?doi=ijp.2007.175.178

 
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