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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 1 | Page No.: 101-105
DOI: 10.3923/ijp.2007.101.105
 
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Effect of Ginsenosides on Malondialdehyde, Nitric Oxide and Endothelin-1 Production in Vascular Endothelial Cells Suffering from Lipid Peroxidation Injury

Tan Jun, Zhu Liancai and Wang Bochu

Abstract:
Ginsenosides are the main effective substance in Panax ginseng and have bioactivity to improve cardiovascular function. In this study, effect of ginsenosides on malondialdehyde (MDA), Nitric Oxide (NO) and endothelin-1 (ET-1) production in human vascular endothelial cells strain VEC304 treated with diamide was studied. The treatment of VEC304 with 0.01 μL · L-1 diamide significantly increased MDA production (p<0.01), significantly decreased NO production (p<0.05) and slightly increased ET-1 production in cells, indicating that diamide induced lipid Peroxidation injury for VEC304. While after VEC304 injured by lipid peroxidation were treated with ginsenosides, MDA production and ET-1 production in cells were decreased significantly (p<0.01) by 29.81 and 38.18%, respectively and NO production in cells was increased significantly (p<0.01) by 6.04 times. The results implied that Panax ginseng and ginsenosides work effectively on cardiovascular diseases probably by anti-oxidation and increasing NO production and decreasing ET-1 production in VEC.
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How to cite this article:

Tan Jun, Zhu Liancai and Wang Bochu, 2007. Effect of Ginsenosides on Malondialdehyde, Nitric Oxide and Endothelin-1 Production in Vascular Endothelial Cells Suffering from Lipid Peroxidation Injury. International Journal of Pharmacology, 3: 101-105.

DOI: 10.3923/ijp.2007.101.105

URL: https://scialert.net/abstract/?doi=ijp.2007.101.105

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