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International Journal of Pharmacology
  Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 348-351
DOI: 10.3923/ijp.2006.348.351
Evaluation of in vivo Antiplasmodial Activity of Aspilia africana
Jude E. Okokon, Lucky L. Nwidu and Grace A. Essiet

Abstract:
The antiplasmodial activity of ethanol leaf extract of Aspilia africana was evaluated in mice infected with Plasmodium berghei berghei during early and established infections. Aspilia africana extract (100-300 mg kg-1 day-1) exhibited a significant (p<0.05) blood schizonticidal activity both in 4 day early infection and in established infection. The extract produced a significant (p<0.05) chemosuppression in both early and established infections tests though lower than that produced by chloroquine, 5 mg kg-1 day-1. Also, significant mean survival time was recorded in extract treated groups compared to the control group during established infection. The leaf extract posseses a promising antiplasmodial activity which can be exploited in malaria therapy.
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How to cite this article:

Jude E. Okokon, Lucky L. Nwidu and Grace A. Essiet , 2006. Evaluation of in vivo Antiplasmodial Activity of Aspilia africana. International Journal of Pharmacology, 2: 348-351.

DOI: 10.3923/ijp.2006.348.351

URL: https://scialert.net/abstract/?doi=ijp.2006.348.351

 
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