• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 2 (1), 2006
  3. 33-41
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2006 | Volume: 2 | Issue: 1 | Page No.: 33-41
DOI: 10.3923/ijp.2006.33.41

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 232

Authors


Anwarul H. Gilani


Muhammad N. Ghayur


Peter J. Houghton


Qaiser Jabeen


Syed F. Kazim


Maliha I. Jumani


Sheikh A. Saeed


Keywords


  • Betel nut
  • hypotensive
  • antiplatelet
  • endothelium-dependent vasodilator
  • cardio-suppressant
  • cholinergic
Research Article

Studies on the Hypotensive, Cardio-suppressant, Vasodilator and Antiplatelet Activities of Betel Nut Crude Extract and its Constituents

Anwarul H. Gilani, Muhammad N. Ghayur, Peter J. Houghton, Qaiser Jabeen, Syed F. Kazim, Maliha I. Jumani and Sheikh A. Saeed
This study reported the hypotensive, cardio-suppressant, endothelium-dependent vasodilator and antiplatelet activities of the crude extract of Areca catechu (Ac.Cr), commonly known as betel nut. Ac.Cr tested positive for the presence of terpenoids, flavonoids, amines, tannins, phenols, alkaloids and saponins and exhibited a dose-dependent (0.1 to 1 mg kg-1) atropine-sensitive fall in the arterial blood pressure of normotensive rats under anaesthesia. In isolated guinea-pig atria, Ac.Cr (0.1 to 10 μg mL-1) showed an atropine-sensitive inhibitory effect on the force and rate of spontaneous atrial contractions. In the endothelium-intact rat aorta, Ac.Cr showed inhibition of the phenylephrine-induced contractions. This relaxant effect was blocked by atropine and L-NAME and was found absent in endothelium-denuded preparations. Ac.Cr (1.0-1.75 mg mL-1) also inhibited arachidonic acid (1.7 mM)-induced human platelet aggregation. Among all the known constituents of betel nut tested, only arecoline showed atropine-sensitive cardio-suppressant and vasodilator effects while catechin exhibited atropine-insensitive vasodilator and also antiplatelet activities. This study shows that betel nut exhibits blood pressure lowering and antiplatelet activities mediated at least partly through the presence of known constituents such as arecoline and catechin, respectively.
PDF References Citation

How to cite this article

Anwarul H. Gilani, Muhammad N. Ghayur, Peter J. Houghton, Qaiser Jabeen, Syed F. Kazim, Maliha I. Jumani and Sheikh A. Saeed, 2006. Studies on the Hypotensive, Cardio-suppressant, Vasodilator and Antiplatelet Activities of Betel Nut Crude Extract and its Constituents. International Journal of Pharmacology, 2: 33-41.

DOI: 10.3923/ijp.2006.33.41

URL: https://scialert.net/abstract/?doi=ijp.2006.33.41

Related Articles

Pharmacological Studies on Antidiarrheal, Gut Modulatory, Bronchodilatory and Vasodilatory Activities of Myrica nagi
Studies on Blood Pressure Lowering, Vasodilator and Cardiac Suppressant Activities of Vitex negundo: Involvement of K+ Channel Activation and Ca++ Channel Blockade
Neem (Azadirachta indica) Lowers Blood Pressure through a Combination of Ca++ Channel Blocking and Endothelium-Dependent Muscarinic Receptors Activation
Blood Pressure Lowering Effect of Morus alba is Mediated Through Ca++ Antagonist Pathway
Antiamnesic and Antioxidant Effect of Acacia catechu-catechin in Normal, Aged and Scopolamine Challenged Cognitive Deficit Mice

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved