Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 324-330
DOI: 10.3923/ijp.2006.324.330
Fibroblast Growth Factor Receptor 3 Up-regulates Vascular Endothelial Growth Factor Expression in L6 Cells
Lijun Zhu, Yun Yen , Jimin Shao , Christina H. Qi , Christina Yen , Jianhong Luo and Bingsen Zhou

Abstract:
Overexpression of Vascular Endothelial Growth Factor (VEGF) has been associated with increased angiogenesis, tumor growth and metastasis in tumors. Fibroblast Growth Factor Receptor 3 (FGFR3) acts as an oncogene in several tumor types, including multiple myeloma, bladder cancer and cervical cancer. Our previous studies have shown that inhibition of FGFR3 caused down regulation of VEGF in multiple myeloma. In order to better understand the molecular mechanism of FGFR3 and VEGF, L6 cells lacking any endogenous FGFR were stably transfected with FGFR3 at the present study. The FGFR3 expression was validated by Northern blot and Western blot. Compared with parental L6 cell and L6V (transfected with vector only), L6 cells with stably transfected FGFR3 showed overexpression of VEGF. [3H] Thymidine uptake and CellTiter 96 Aqueous One Solution cell proliferation assay demonstrated that DNA synthesis and cell proliferation were increased in FGFR3 expression L6 cells. These observations indicate that FGFR3 might be associated with regulation of VEGF, suggesting that combinations of inhibition of VEGF and inhibition of FGFR3 may have an advantage for the treatment of FGFR3 overexpression neoplastic disease.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Association of VEGF with Regional Lymph Node Metastasis in Breast IDC
How to cite this article:

Lijun Zhu, Yun Yen , Jimin Shao , Christina H. Qi , Christina Yen , Jianhong Luo and Bingsen Zhou , 2006. Fibroblast Growth Factor Receptor 3 Up-regulates Vascular Endothelial Growth Factor Expression in L6 Cells. International Journal of Pharmacology, 2: 324-330.

DOI: 10.3923/ijp.2006.324.330

URL: https://scialert.net/abstract/?doi=ijp.2006.324.330

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom