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International Journal of Pharmacology
  Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 320-323
DOI: 10.3923/ijp.2006.320.323
The Effect of Sulphamethazine Combination on the Plasma Kinetics of Chloramphenicol in Sokoto Red Goats
E.U. Etuk, P.A. Onyeyili and S.O. Bello

Abstract:
A comparative pharmacokinetic study of chloramphenicol (25 mg kg-1 intravenous) by chemical assay method and its combination with sulphamethazine (33 mg kg-1) in Sokoto red goats has revealed that the mean peak plasma concentrations at 0.08 h post drug administration were not significantly different. However, various pharmacokinetic parameters were significantly altered (p<0.05) after the combination therapy; the total body clearance (Cl) and elimination constant (β) were significantly higher whereas the half life of elimination (t½ β) and the distribution rate constant were significantly lower. These changes observed in this study could be an indication that, the combination therapy may require a reduced chloramphenicol dose without necessarily minimising the efficiency of the drug and this may also possibly reduce the risk of dose-related toxicity.
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How to cite this article:

E.U. Etuk, P.A. Onyeyili and S.O. Bello , 2006. The Effect of Sulphamethazine Combination on the Plasma Kinetics of Chloramphenicol in Sokoto Red Goats. International Journal of Pharmacology, 2: 320-323.

DOI: 10.3923/ijp.2006.320.323

URL: https://scialert.net/abstract/?doi=ijp.2006.320.323

 
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