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International Journal of Pharmacology
  Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 298-302
DOI: 10.3923/ijp.2006.298.302
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Long-Term Application of 0.1% Dexamethasone May Affect the Lens Capsular Lipids

S.M. Sherif and A.A. Salwa

Dexamethasone, one of the most potent glucocorticoids, is very effective anti-inflammatory drug. A side effect associated with long-term treatment of various diseases with steroids is a high incidence of posterior subcapsular cataracts. The literature did not indicate any reports discuss if the treatment with 0.1% dexamethasone has any effect(s) on the lens capsule or not. To answer this the lens capsule lipids was studied using different techniques. NewZealand albino rabbits were used in this study, where three groups were involved; control, 3DEXA and 5DEXA groups. Dexamethasone was instilled in both eyes four times a day for three weeks (3DEXA) and for five weeks (5DEXA). The measured parameters: total lipids, cholesterol, phospholipids and total protein as well as lipid spectroscopy (UV and FTIR) revealed significant changes in the capsular thickness as well as the physical characteristics of the capsular lipid bilayer.
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How to cite this article:

S.M. Sherif and A.A. Salwa , 2006. Long-Term Application of 0.1% Dexamethasone May Affect the Lens Capsular Lipids. International Journal of Pharmacology, 2: 298-302.

DOI: 10.3923/ijp.2006.298.302






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