Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2006 | Volume: 2 | Issue: 1 | Page No.: 142-145
DOI: 10.3923/ijp.2006.142.145
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Vasorelaxant Effects of Sildenafil and Verapamil on Isolated Rat Aorta with and without Intact Endothelium

Hanefi Ozbek , Beyhan Eryonucu and Niyazi Guler

Abstract:
This study was designed to compare vasorelaxant effects of the sildenafil and verapamil on isolated rat aorta. Endothelium intact and denuded aortic rings were suspended in organ chambers. Sildenafil (10-10 to 10-4 M) induced a dose-dependent vasodilation of phenylephrine precontracted aortic rings. Relaxation of endothelium intact and denuded aortic rings caused by 10-4 M sildenafil was about 96 and 79%, respectively. Verapamil (10-10 to 10-4 M) induced a dose-dependent vasodilation of phenylephrine precontracted aortic rings. Relaxation of endothelium intact and denuded aortic rings caused by 10-4 M verapamil was about 99 and 98%, respectively. In the phenylephrine precontracted aortic rings, pD2 values for sildenafil were 4.93±0.59 and 4.11±0.62 in the presence and absence of endothelium, respectively. The pD2 values for verapamil were not different in the presence and absence of endothelium (5.15±1.05 vs 4.96±1.14). Verapamil and sildenafil showed a similar degree of vasorelaxant effect in the intact aortic rings, although there was a significant difference in the degree of relaxation in the absence of endothelium (98 vs 79%). Sildenafil induced both endothelium-dependent and independent vasorelaxation on the aortic rings. Although, there was no significant difference in the degree of relaxation induced by verapamil and sildenafil in aortic rings with intact endothelium, verapamil has more relaxing effect in the denuded aortic rings.
PDF References Citation Report Citation
 RELATED ARTICLES:
  •    The Characteristics of Contractions to Hyperosmolar Stress in Rat Aorta
How to cite this article:

Hanefi Ozbek , Beyhan Eryonucu and Niyazi Guler, 2006. Vasorelaxant Effects of Sildenafil and Verapamil on Isolated Rat Aorta with and without Intact Endothelium. International Journal of Pharmacology, 2: 142-145.

DOI: 10.3923/ijp.2006.142.145

URL: https://scialert.net/abstract/?doi=ijp.2006.142.145

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom