• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 1 (3), 2005
  3. 267-276
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2005 | Volume: 1 | Issue: 3 | Page No.: 267-276
DOI: 10.3923/ijp.2005.267.276

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 64

Authors


Sathyanarayanan Srinivasan


Balasubramanian Karundevi


Keywords


Research Article

Comparative Evaluation of Hypoglycaemic Activity of Two Medicinal Plants in Alloxan Diabetic Rats

Sathyanarayanan Srinivasan and Balasubramanian Karundevi
Aqueous extracts of the seeds of fenugreek (Trigonella foenum graecum) and fruits of bitter gourd (Momordica charantia) were tested for their hypoglycemic activity. The aqueous extracts or just the solvent alone (control) were orally administered daily for 7 days (short term) or 15 days (long term) to alloxan-induced diabetic rats. Blood glucose and plasma insulin levels and the subsequent effect on Oral Glucose Tolerance Test (OGTT) were monitored at 3, 6 and 9 h after the last administration. Daily administration of T. foenum graecum for 7 days failed to induce any significant change in the blood glucose levels. However, an extended 15-day treatment regimen was found to significantly reduce the blood glucose levels. The blood glucose levels were found to decrease at 6 and 9 h after the final administration of the extract. In contrast, both 7 and 15 days daily administration of M. charantia reduced the blood glucose levels drastically (p<0.05 and p<0.01, respectively). Significant reduction in blood glucose levels was observed at 6 and 9 h after the short-term treatment and at 3, 6 and 9 h after the long-term treatment. Long term administration of both T. foenum graecum and M. charantia was found to decrease blood glucose levels during OGTT at 30, 60 and 90 min when compared to OGTT of diabetic animals. There was no change in plasma insulin levels subsequent to administration of either T. foenum graecum or M. charantia. The observed results indicate that T. foenum graecum and M. charantia have hypoglycemic effect. The fact that the plasma insulin levels were unaltered suggests that the probable mechanism does not involve β-cell and may be attributable to decrease in intestinal absorption of glucose.
PDF References Citation

How to cite this article

Sathyanarayanan Srinivasan and Balasubramanian Karundevi, 2005. Comparative Evaluation of Hypoglycaemic Activity of Two Medicinal Plants in Alloxan Diabetic Rats. International Journal of Pharmacology, 1: 267-276.

DOI: 10.3923/ijp.2005.267.276

URL: https://scialert.net/abstract/?doi=ijp.2005.267.276

Related Articles

Assessment of Diosgenin Production by Trigonella foenum-graecum L. in vitro Condition
Purified Methanolic Extract of Salacia reticulata Wight. Ameliorates Insulin Resistance and Metabolic Alterations in Rats Fed High Fructose Diet

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved