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  1. International Journal of Pharmacology
  2. Vol 1 (3), 2005
  3. 261-266
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International Journal of Pharmacology

Year: 2005 | Volume: 1 | Issue: 3 | Page No.: 261-266
DOI: 10.3923/ijp.2005.261.266

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Authors


Mosaad Sayed Mohamed


Mohamed Kamal Ibrahim


Ahmed Mahmoud Alafify


Sami Gaber Abdel-Hamide


Adel M. Mostafa


Keywords


Research Article

Synthesis and Anti-inflammatory Evaluation of Some New Quinazoline Derivatives

Mosaad Sayed Mohamed, Mohamed Kamal Ibrahim, Ahmed Mahmoud Alafify, Sami Gaber Abdel-Hamide and Adel M. Mostafa
A series of new 5-(4-chlorophenyl)-9-iodo-3-substituted-1,2,4-triazolo[4,3-c]quinazoline and 2- (4-chlorophenyl)-6-iodo-4-substituted-quinazoline was prepared via several synthetic routes. Some of the compounds were prepared by cyclization of 2-(4-chlorophenyl)-4-chloro-6-iodoquinazoline with semicarbazide or acid hydrazide; other compounds were obtained from reaction of 2-(4-chlorophenyl)-4-chloro-6-iodoquinazoline with some amines and amino acid esters. The synthesized compounds were evaluated as anti-inflammatory agents through the carrageenin-induced paw edema test. The screening data revealed that nine of the tested compounds have activity comparable to indomethacin.
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How to cite this article

Mosaad Sayed Mohamed, Mohamed Kamal Ibrahim, Ahmed Mahmoud Alafify, Sami Gaber Abdel-Hamide and Adel M. Mostafa, 2005. Synthesis and Anti-inflammatory Evaluation of Some New Quinazoline Derivatives. International Journal of Pharmacology, 1: 261-266.

DOI: 10.3923/ijp.2005.261.266

URL: https://scialert.net/abstract/?doi=ijp.2005.261.266

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