Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2005 | Volume: 1 | Issue: 3 | Page No.: 261-266
DOI: 10.3923/ijp.2005.261.266
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Synthesis and Anti-inflammatory Evaluation of Some New Quinazoline Derivatives

Mosaad Sayed Mohamed , Mohamed Kamal Ibrahim , Ahmed Mahmoud Alafify , Sami Gaber Abdel-Hamide and Adel M. Mostafa

Abstract:
A series of new 5-(4-chlorophenyl)-9-iodo-3-substituted-1,2,4-triazolo[4,3-c]quinazoline and 2- (4-chlorophenyl)-6-iodo-4-substituted-quinazoline was prepared via several synthetic routes. Some of the compounds were prepared by cyclization of 2-(4-chlorophenyl)-4-chloro-6-iodoquinazoline with semicarbazide or acid hydrazide; other compounds were obtained from reaction of 2-(4-chlorophenyl)-4-chloro-6-iodoquinazoline with some amines and amino acid esters. The synthesized compounds were evaluated as anti-inflammatory agents through the carrageenin-induced paw edema test. The screening data revealed that nine of the tested compounds have activity comparable to indomethacin.
PDF References Citation Report Citation
 RELATED ARTICLES:
  •    Isolation, Characterization and Pharmacological Evaluation of 8-chloro-3 (1-methyl-piperidene-4-yl) 5H-benzo [5, 6] Cyclohepta [1, 2b] Pyridene-11(6H)-one from Loratadine
How to cite this article:

Mosaad Sayed Mohamed , Mohamed Kamal Ibrahim , Ahmed Mahmoud Alafify , Sami Gaber Abdel-Hamide and Adel M. Mostafa , 2005. Synthesis and Anti-inflammatory Evaluation of Some New Quinazoline Derivatives. International Journal of Pharmacology, 1: 261-266.

DOI: 10.3923/ijp.2005.261.266

URL: https://scialert.net/abstract/?doi=ijp.2005.261.266

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom