
	International Journal of Pharmacology
	Year: 2005 \| Volume: 1 \| Issue: 3 \| Page No.: 261-266 DOI: 10.3923/ijp.2005.261.266

Synthesis and Anti-inflammatory Evaluation of Some New Quinazoline Derivatives

Mosaad Sayed Mohamed , Mohamed Kamal Ibrahim , Ahmed Mahmoud Alafify , Sami Gaber Abdel-Hamide and Adel M. Mostafa

Abstract: A series of new 5-(4-chlorophenyl)-9-iodo-3-substituted-1,2,4-triazolo[4,3-c]quinazoline and 2- (4-chlorophenyl)-6-iodo-4-substituted-quinazoline was prepared via several synthetic routes. Some of the compounds were prepared by cyclization of 2-(4-chlorophenyl)-4-chloro-6-iodoquinazoline with semicarbazide or acid hydrazide; other compounds were obtained from reaction of 2-(4-chlorophenyl)-4-chloro-6-iodoquinazoline with some amines and amino acid esters. The synthesized compounds were evaluated as anti-inflammatory agents through the carrageenin-induced paw edema test. The screening data revealed that nine of the tested compounds have activity comparable to indomethacin.

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How to cite this article:

Mosaad Sayed Mohamed , Mohamed Kamal Ibrahim , Ahmed Mahmoud Alafify , Sami Gaber Abdel-Hamide and Adel M. Mostafa , 2005. Synthesis and Anti-inflammatory Evaluation of Some New Quinazoline Derivatives. International Journal of Pharmacology, 1: 261-266.

DOI: 10.3923/ijp.2005.261.266

URL: https://scialert.net/abstract/?doi=ijp.2005.261.266

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