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International Journal of Pharmacology
  Year: 2005 | Volume: 1 | Issue: 2 | Page No.: 157-160
DOI: 10.3923/ijp.2005.157.160
Protective Effects of Sildenafil and Dipyridamol from Lead-induced Lipid Peroxidation in Perfused Rat Liver
Ramesh Aghababaeian, Mahmoud Ghazi-Khansari , Khosrou Abdi , Fakhreldin Taghadosinejad and Mohammad Abdollahi

Abstract:
This study was designed to explore the protective effects of sildenafil and dipyridamole from toxicity of lead in an established model of rat liver perfusion. The rats were anesthetized with ketamine and chlorpromazine. The portal vein and the inferior vena cava were cannulated and the liver was perfused in situ through the portal vein with Krebs-Henseleit buffer. After 25 min of equilibration, lead (0.5 mM) and drugs (sildenafil 50 μM, dipyridamole 50 μM) were perfused for 45 min and samples of perfused fluid were collected for assessment of thiobarbituric reactive substances as index of lipid peroxidation. Lead treatment induced a marked lipid peroxidation. Cotreatment with sildenafil and dipyridamole significantly reduced lead-induced lipid peroxidation but did not reach control values. It is concluded that lead toxicity is mediated through lipid peroxidation in rat liver which is preventable with sildenafil and dipyridamole. This action of sildenafil and dipyridamole backs to their potential to increase intracellular cGMP which seems playing as an antioxidant.
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How to cite this article:

Ramesh Aghababaeian, Mahmoud Ghazi-Khansari , Khosrou Abdi , Fakhreldin Taghadosinejad and Mohammad Abdollahi , 2005. Protective Effects of Sildenafil and Dipyridamol from Lead-induced Lipid Peroxidation in Perfused Rat Liver. International Journal of Pharmacology, 1: 157-160.

DOI: 10.3923/ijp.2005.157.160

URL: https://scialert.net/abstract/?doi=ijp.2005.157.160

 
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