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International Journal of Pharmacology
Reconsidering a Citrus Flavonoid Naringin as a Promising Nutritional Supplement and its Beneficial Health Applications in Humans, Animals and Poultry
Li Changxing, Muhammad Saeed, Asghar Ali Kamboh, Mahmoud Alagawany, Mohamed E. Abd El-Hack, Muhammad Asif Arain, Daryoush Babazadeh, Kuldeep Dhama and Mo Chenling

Flavonoids are ubiquitous plant metabolites, constitute an important group of natural compounds with various biologic activities and have been the subject of great interest for scientific research. Citrus flavonoids have been established as an important sub-class of flavonoids. Naringin is a prime example that is a natural flavanone glycoside, found mainly in grapefruits, grapes, tomatoes and citrus fruits as well. Citrus flavanones like naringin play an important role as anti-inflammatory, anti-oxidant, anti-apoptotic, antidepressant, hypolipidemic, immunoregulatory, hepatoprotective, wound healing, anti-diabetic and antihyperglycemic agent. It constitutes a major category of nature-derived bioactive compounds, has potent anti-oxidant and anti-inflammatory effects that render it as a promising dietary supplement in animal and poultry feeds. The use of these natural anti-oxidants can also play a vital role to extend the shelf life and increase the consumers’ acceptability for meat and meat products. Both in vivo and in vitro studies have recognized the worth of naringenin several preclinical models of neurodegenerative disorders, cardiovascular diseases, osteoporosis, atherosclerosis, rheumatological disorders and diabetes mellitus. Moreover, it plays a chief role in lowering cholesterol, triglycerides and improvements in immune functions and anti-oxidant status, as reported in human and different animal model studies. This flavonoid has faced limited research and usage in the poultry production industry, although it has many promising biological effects. So this review paper aims to compile the important biologic activities of this compound in order to promote more studies pertaining to this citrus flavonoid, which could be used as a natural feed additive to improve health and meat quality and its potential to lower medicinal cost in animal and poultry industry.
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