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International Journal of Dairy Science

Year: 2017 | Volume: 12 | Issue: 2 | Page No.: 143-148
DOI: 10.3923/ijds.2017.143.148

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Authors


Moetazza M. Alshafei

Country: Egypt

Seham S. Kassem

Country: Egypt

Azzat B. El-Khalek

Country: Egypt

Mohamed T. Fouad

Country: Egypt

Enas N. Danial

Country: Saudi Arabia

Emtenan M. Hanafi

Country: Egypt

Maha M. Saber

Country: Egypt

Eitedal M. Daoud

Country: Egypt

Keywords


  • bone mineral density
  • Osteoporosis
  • dairy product
  • L. reuteri
  • phytase
Research Article

Lactobacillus reuteri can Improve BMD in Patients Having Bone Fragility

Moetazza M. Alshafei, Seham S. Kassem, Azzat B. El-Khalek, Mohamed T. Fouad, Enas N. Danial, Emtenan M. Hanafi, Maha M. Saber and Eitedal M. Daoud
Background: Osteopenia or osteoporosis translates as "porous bones" or when the holes between bone become bigger, making it fragile and liable to break easily. Practically, osteoporosis is translated to Bone Mineral Density (BMD). Aged women are in higher risk due to amenorrhea, higher calcium loss in urine, immobilization, low mineral supplementation and absorption. Some antinutritive factors such as phytate accumulates in the seeds (wheat, maize, rice, soya bean, etc) during the ripening period. The unique structure of phytic acid offers it the ability to strongly chelate with cations such as calcium, magnesium, zinc, copper, iron and potassium to form insoluble salts. It therefore adversely affects the absorption and digestion of these minerals and consequently affects bone formation in monogastric animals and human because they lack the intestinal digestive enzyme phytase. Foods supplementation of some enzyme such as phytase and acid phosphatase in diets results in increase in mineral absorption. Phytase and acid phosphatase are two enzymes produced by some Lactobacillus bacteria, L. reuteri. Objective: The current study was to investigate the valuable effect of dairy product (yoghurt) enriched with phytase producing bacteria in improving mineralization of bone in postmenopausal women. Methodology: Two enzymes (phytase and acid phosphatase) have been collected from Lactobacillus reuteri. Both enzymes activity were evaluated in stored yoghurt for 11 days to estimate the duration of enzyme activity. Twelve patients proved to have either osteopenia or osteoporosis were enrolled in the study. Patients accepted to eat our dairy product for 2 months, with diet rich in grains. They gave full data about their nutritional habits. They provided blood samples and carried out DEXA for estimation of BMD at the start and end of the study period. Results: The study showed that both enzymes, phytase and acid phosphatase were active for long time and wide range of acidity suggesting high activity in both stomach and intestine. The DEXA showed improved BMD in patients under investigation, elevation in serum mineral concentration and elevation of serum antioxidants markers also were demonstrated. Conclusion: The study concluded that consumption of our dairy product may be promising treatment for patients having bone fragility.
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How to cite this article

Moetazza M. Alshafei, Seham S. Kassem, Azzat B. El-Khalek, Mohamed T. Fouad, Enas N. Danial, Emtenan M. Hanafi, Maha M. Saber and Eitedal M. Daoud, 2017. Lactobacillus reuteri can Improve BMD in Patients Having Bone Fragility. International Journal of Dairy Science, 12: 143-148.

DOI: 10.3923/ijds.2017.143.148

URL: https://scialert.net/abstract/?doi=ijds.2017.143.148

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