The biological function of colostrums in all lactating species is the growth and health of a newborn offspring. In bovine colostrum, the naturally occurring antibodies (immunoglobulins) provide a marked antimicrobial effects against a wide range of microbes and confer a passive immunity until the calfs immune system has matured. The concentration of specific antibodies in mammary secretions against a certain pathogens microorganism can be raised in colostrum and milk by immunizing cows with these pathogens or their antigens. Such hyperimmune colostrum and milk or antibodies isolated from it provide an increased specific protection against different enteric diseases in calves. Colostral immunoglobulin preparations designed for farm animals are commercially available in many countries and also some colostrum based products are marketed for humans as dietary supplements. Clinical studies are now in progress in many countries to evaluate the potential of immune milk products as preventative treatment for various hospital infections, especially those caused by antibiotic resistant bacteria and Helicobacter pylori, the causative agent of chronic gastritis. This article reviews the recent progress made in the properties of bovine immunoglobulins, their isolation from colostrum and utilization in the preparation of bovine immune milk for prevention and treatment of microbial infections in humans and animals.