Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Dairy Science
  Year: 2007 | Volume: 2 | Issue: 2 | Page No.: 126-137
DOI: 10.3923/ijds.2007.126.137
Impact of Whey Proteins on the Genotoxic Effects of Aflatoxins in Rats
H. Sekena Abd EL-Aziem , A. Zeinab Saleh and A.F. Farrag

Abstract:
The purpose of this study is to investigate the possible antimutagenic effects of whey proteins against genotoxic effects induced by aflatoxins in the mammalian cell system. The micronuclei, chromosomal abnormalities in both somatic and germ cells as well as DNA titrations in male rats were assayed. Whey proteins was added to the diet containing aflatoxins (2.5 mg AFs kg-1) and fed to mature male rats for 9 weeks. The results indicated that aflatoxin significantly (p<0.001) increased chromosomal abnormalities in somatic and germ cells, DNA titration and micronuclei of bone marrow cells. Addition of whey proteins to the aflatoxins contaminated diet resulted a significant decrease in chromosomal aberrations in somatic cells (62.8%, p<0.001), in germ cells (57.9%, p<0.01) and in micronuclei polychromatic erythrocytes (68.2%, p<0.001). It could be concluded that whey protein reduced the mutagenesis and clastogenesis effects of AFs. Although the mechanism of antimutagenicity is unknown, it seems plausible that the whey proteins acts as a blocking agent by chemical or physical interaction with the mutagens. Furthermore, this study revealed that the addition of whey proteins to aflatoxin contaminated diet diminished most of the genotoxic effects of the Aflatoxin.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Anti-mutagenic and Anti-genotoxic Effect of Ethanolic Extract of Neem on Dietary-aflatoxin Induced Genotoxicity in Mice
How to cite this article:

H. Sekena Abd EL-Aziem , A. Zeinab Saleh and A.F. Farrag , 2007. Impact of Whey Proteins on the Genotoxic Effects of Aflatoxins in Rats . International Journal of Dairy Science, 2: 126-137.

DOI: 10.3923/ijds.2007.126.137

URL: https://scialert.net/abstract/?doi=ijds.2007.126.137

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 

       

       

Curve Bottom