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International Journal of Cancer Research
  Year: 2020 | Volume: 16 | Issue: 1 | Page No.: 28-34
DOI: 10.3923/ijcr.2020.28.34
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Expression of Aberrant Antigens in Adult Acute Leukemia: A Study in Bangladesh

Asif Rashed, Shirin Tarafder , Humayun Sattar and Sadia Hossain

Background and Objective: Aberrant antigen expression can adversely influence the clinical response, remission rate and overall survival in patients with acute leukemia. The aim of this study was to observe the frequency of expression of aberrant antigens in Acute Leukemia (AL) of adult patients. Materials and Methods: A cross sectional prospective study of acute leukemia was done over one year period (March, 2015-February, 2016). Multi parametric Flow Cytometric Immunophenotyping (FCI) was performed on peripheral blood and/or bone marrow aspirates collected from provisionally diagnosed acute leukemia patients of age >18 years. The FCI was performed with a complete panel of fluorochrome monoclonal antibodies. The co-expression of CD markers on myeloid and lymphoid population was analyzed. Results: A total of 64 AL cases were diagnosed by FCI, of which 31 cases had Acute Myeloid Leukemia (AML), 21 had B-Acute Lymphatic Leukemia (ALL) and 10 T-ALL. The remaining 2 cases (3.1%) were diagnosed as Mixed Phenotype Acute Leukemia (MPAL). Overall 40.3% (25/62) of the patients showed expression of aberrant CD markers. Among the 31 AML cases, aberrant expression of CD7 was in 7 (22.5%) cases followed by CD19 (12.9%) 4/31 and TdT (3.2%) 1/31 cases. Among 21 B-ALL cases aberrantly expressed antigens were CD13 (23.8%) 5/21 and CD33 (19.05%) 4/21. Of the 10 T-ALL cases, CD33 was expressed in 2(20%) cases and cyCD79a, CD117 and CD13 in (10%) 1/10 case each. Both cyCD79a and CD13 was expressed in one case. Conclusion: Quest for aberrant antigen expression should be given adequate emphasis as this may be of prognostic value.
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How to cite this article:

Asif Rashed, Shirin Tarafder, Humayun Sattar and Sadia Hossain, 2020. Expression of Aberrant Antigens in Adult Acute Leukemia: A Study in Bangladesh. International Journal of Cancer Research, 16: 28-34.

DOI: 10.3923/ijcr.2020.28.34






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