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International Journal of Cancer Research
  Year: 2018 | Volume: 14 | Issue: 1 | Page No.: 21-26
DOI: 10.3923/ijcr.2018.21.26
 
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Deletion of the Alu Repeat in the Tissue Plasminogen Activator (tPA) Gene For Protection of Breast Cancer

Lubna H. Tahtamouni , Zainab A. Al-Mazaydeh , Rema A. Al-Khateeb, Reem N. Abdellatif and Salem R. Yasin

Abstract:
Background and Objective: Breast cancer is the most common malignant tumor and the major cause of death from cancer among women worldwide. Objective of the current study was to investigate the possible association between an Alu polymorphism in the Tissue Plasminogen Activator (tPA) gene (PLAT ) with breast cancer. Methodology: Using the Polymerase Chain Reaction (PCR) on genomic DNA isolated from breast cancer patients (n = 73) and an age-matched normal individuals (n = 44), a region polymorphic for an Alu element insertion in the tPA gene was amplified. Results: The percentage of normal Jordanian individuals who were homozygotes for the absence of the Alu insert (Alu–/‾) was 84.1%, while 15.9% were homozygotes for the presence of the Alu insert (Alu+/+). No heterozygosity (Alu+/‾) was detected in this study group. On the other hand, 22 (30.14%) breast cancer patients exhibited the Alu–/‾ genotype, 29 (39.73%) were Alu+/‾ and 22 (30.14%) were Alu+/+. The Alu–/‾ genotype occurred 2.8 times more frequently in the normal individuals than in the breast cancer patients (p<0.001). Conclusion: The predominance of the Alu–/‾ genotype of the tissue plasminogen activator (tPA) gene within the normal group represents a protective deletion with respect to breast cancer.
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How to cite this article:

Lubna H. Tahtamouni, Zainab A. Al-Mazaydeh, Rema A. Al-Khateeb, Reem N. Abdellatif and Salem R. Yasin, 2018. Deletion of the Alu Repeat in the Tissue Plasminogen Activator (tPA) Gene For Protection of Breast Cancer. International Journal of Cancer Research, 14: 21-26.

DOI: 10.3923/ijcr.2018.21.26

URL: https://scialert.net/abstract/?doi=ijcr.2018.21.26

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