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International Journal of Cancer Research
  Year: 2017 | Volume: 13 | Issue: 1 | Page No.: 1-8
DOI: 10.3923/ijcr.2017.1.8
 
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High Level Amplifications of AKT3, SDCCAG8 and SLC35F3 Genes at Chromosomal 1q42.2-44 Region in Non-small Cell Lung Cancer: Early and Prognostic Implications

Jiun Kang

Abstract:
Background: Genomic alterations in the early stage of Non-Small Cell Lung Cancer (NSCLC) have a tight relationship with tumor initiation and potentially activate downstream pathways that are implicated in tumor progression. Methodology: In this study, the most salient and consistent finding was frequentcopy number gains (log2 ratio >0.25) at the long of chromosome 1, which occurred in 78.3% (18/23) of stage I/II NSCLC cases and the delineated minimal common region was 1q21.1-q44. More importantly, three distinct regions of amplifications in the 1q21.1-q44 region were detected in 17.4% (4/23) of the cases. Results: Among these amplified loci, the 1q44 locus comprises AKT3 are presentative oncogene. In addition, SDCCAG8 (1q44) and SLC35F3 (1q42.2) genes were identified as probable genetic targets within the amplicon (12.5%), which have not been previously considered to play a pathogenic role in NSCLCs. These findings suggested that genetic alterations on chromosome 1q are the first step in the initiation of the genomic instability contributing to early NSCLC development. Conclusion: The newly identified genes at the 1q42.2-q44 amplified chromosomal region might be of interest for further studies of the pathophysiology of the early stages of NSCLC and are indicated as potential therapeutic targets.
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How to cite this article:

Jiun Kang , 2017. High Level Amplifications of AKT3, SDCCAG8 and SLC35F3 Genes at Chromosomal 1q42.2-44 Region in Non-small Cell Lung Cancer: Early and Prognostic Implications. International Journal of Cancer Research, 13: 1-8.

DOI: 10.3923/ijcr.2017.1.8

URL: https://scialert.net/abstract/?doi=ijcr.2017.1.8

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