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International Journal of Cancer Research

Year: 2015 | Volume: 11 | Issue: 2 | Page No.: 80-92
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Authors

T.G.C. Uy

A.M. Licuanan

G.E.D. Angeles

M.L.C.C. Bote

E.A.B. Macauyag

C.C. Hernandez

S.D. Jacinto

R.M. Guzman-Genuino

Keywords

Mikania cordata is a medicinal plant traditionally used as an antibacterial, anti-ulcer, anti-inflammatory, antihelmintic and analgesic agent. The potential of M. cordata as an anti-cancer agent has not been explored thus far. This study aims to assess M. cordata as a possible anti-cancer agent, specifically against MCF-7 breast cancer cells. Ethanol extract-vacuum liquid chromatography fractions inhibited proliferation of the MCF-7 cells via different mechanisms. Fraction 6 induces non-specific cytotoxicity via apoptosis and oxidative pathways demonstrated by the TUNEL and DPPH assays. Fractions 7, 10 and 11 exhibit selective cytotoxicity against MCF-7 breast cancer cells but does so through mechanisms other than apoptosis and oxidation. The results suggest that novel mechanisms of action may be at work, imparting cancer-specific cytotoxicity properties of these fractions. Phytochemical screening suggests terpenes and saponins as the possible anti-cancer agent in M. cordata.
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How to cite this article

T.G.C. Uy, A.M. Licuanan, G.E.D. Angeles, M.L.C.C. Bote, E.A.B. Macauyag, C.C. Hernandez, S.D. Jacinto and R.M. Guzman-Genuino, 2015. Anti-Cancer Effect and Mechanisms of Action of Mikania cordata Plant Extract on MCF-7 Human Breast Adenocarcinoma Cells. International Journal of Cancer Research, 11: 80-92.

DOI: 10.3923/ijcr.2015.80.92

URL: https://scialert.net/abstract/?doi=ijcr.2015.80.92

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