Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Cancer Research
  Year: 2015 | Volume: 11 | Issue: 4 | Page No.: 186-196
DOI: 10.3923/ijcr.2015.186.196
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Tumoricidal Property of Normoxia and Hypoxia Cell-Free Lysate of Wharton’s Jelly-Mesenchymal Stem Cells Toward Various Cancer Cells

Wahyu Widowati, Laura Wijaya, Dwi Agustina, Harry Murti, Nurul Fauziah, Sutiman B. Sumitro, M. Aris Widodo and Indra Bachtiar

Abstract:
Cancer is one of the leading causes of mortality and morbidity throughout the world. Since there are still some problems related to the conventional therapies for cancer treatment, it is critical to explore new more efficient therapy strategies. Mesenchymal Stem Cells (MSCs) are one of powerful tools for tissue engineering for regenerative medicine, as recent research aims to utilize MSCs for anti-cancer treatment. Our previous research demonstrated that Conditioned Medium from Whartons’ Jelly MSCs (WJ-MSCs-CM) significantly lowered cancer proliferation of various cancer cell lines. This research was performed to evaluate the tumoricidal property of cell lysate from WJ-MSCs from normoxia (WJMSCs-norCL) and hypoxia-treated WJMSCs (WJMSCs-hypoCL) on the proliferation of human cancer cells, including cervical (HeLa), liver (HepG2), ovarian (SKOV3) and oral squamous (HSC3) cancer cell lines compared to normal cells including mouse fibroblast (NIH3T3), human Mesenchymal Stem Cells (hMSCs), human fibroblast. The WJMSCs-norCL and WJMSCs-hypoCL have cytotoxic activity, reduce proliferation of various cancer cell lines with minimum inhibitory concentration (IC50) 21.094-95.928 μg mL–1 and no cytotoxic to normal cells with IC50 409, 191-629, 799.738 μg mL–1. The WJMSCs-norCL and WJMSCs-hypoCL inhibit proliferation in various cancer cell lines and are not toxic for normal cells.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Wahyu Widowati, Laura Wijaya, Dwi Agustina, Harry Murti, Nurul Fauziah, Sutiman B. Sumitro, M. Aris Widodo and Indra Bachtiar, 2015. Tumoricidal Property of Normoxia and Hypoxia Cell-Free Lysate of Wharton’s Jelly-Mesenchymal Stem Cells Toward Various Cancer Cells. International Journal of Cancer Research, 11: 186-196.

DOI: 10.3923/ijcr.2015.186.196

URL: https://scialert.net/abstract/?doi=ijcr.2015.186.196

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 

Curve Bottom