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International Journal of Cancer Research
  Year: 2014 | Volume: 10 | Issue: 2 | Page No.: 81-95
DOI: 10.3923/ijcr.2014.81.95
 
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ABO Blood Group and Risk of Malignancies in Egyptians

A.H. Mansour, Mohammed Amin Mohammed, Rokia Anwar, M.E. Elzafrany and Nesreen Moustafa Omar

Abstract:
There is growing evidence that the ABO blood group system may play a role in disease etiology. Studies conducted several decades ago, have demonstrated a relationship between inherited human ABO and Rhesus blood groups and risk of various malignancies. However, these findings are inconsistent and contradictory. The objective was to perform analysis of ABO and Rhesus blood antigens distribution among patients with various cancers including breast, hepatocellular, pancreatic, gastric, skin, lung cancers, leukemia and lymphoma in Dakahlia, Egypt and to assess their potential role in carcinogenesis. A total of 1131 cancer patients (age 63.8±9.3, female/male, 215/916) and another 1200 healthy controls (age 48.9±11.3, female/male, 348/852) were enrolled in this study. ABO blood groups were determined using Tube method and Gel method. The anti-TF IgG level and Von Willebrand factor were determined by enzyme-linked immunosorbent assay. The distribution of blood type A was significantly higher among cancer patients than among healthy controls (39.35 vs. 33.75%, p = 0.014), whereas, the distributions of other blood types were similar between cases and controls (p>0.05). Most cancers, especially gastrointestinal tumors were dominated by male gender independent of age. Blood group A was associated with significantly higher risk for malignancy including hepatocellular carcinoma, pancreatic and breast cancers while biliary and esophageal cancer risk was significantly associated with blood type B. We suggest that blood group A may elevate risk of cancer and may play a role in its development.
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How to cite this article:

A.H. Mansour, Mohammed Amin Mohammed, Rokia Anwar, M.E. Elzafrany and Nesreen Moustafa Omar, 2014. ABO Blood Group and Risk of Malignancies in Egyptians. International Journal of Cancer Research, 10: 81-95.

DOI: 10.3923/ijcr.2014.81.95

URL: https://scialert.net/abstract/?doi=ijcr.2014.81.95

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