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International Journal of Cancer Research
  Year: 2014 | Volume: 10 | Issue: 1 | Page No.: 27-36
DOI: 10.3923/ijcr.2014.27.36
Inhibitory Effect of Lentils, Green Split and Yellow Peas (Sprouted and Non-sprouted) on Azoxymethane-induced Aberrant Crypt Foci in Fisher 344 Male Rats
K. Busambwa, R.L. Miller-Cebert, L. Aboagye, L. Dalrymple, J. Boateng, L. Shackelford, L.T. Walker and M. Verghese

Abstract:
Peas (yellow and green) and lentils contain bioactive compounds with protective properties. Sprouting of grains has shown to improve nutritional value due to activation of hydrolytic enzymes. The aim of this study was to determine anticarcinogenic potential of sprouted and non-sprouted green-split and yellow peas and lentils at 5 and 10% on Azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF) in Fisher 344 male rats. Seventy-eight rats were randomly assigned to 13 groups: Control (C) received AIN-93G diet; treatment diets included Lentils sprouted and non-sprouted (LS, LNS), Green peas sprouted and non-sprouted (GS, GNS), Yellow peas sprouted and non-sprouted (YS, YNS) at 5 and 10% levels in an AIN 93 based diet. At 7 and 8 week, rats received 2 subcutaneous injections of AOM at 16 mg kg-1 b.wt. Rats were euthanized at 17 week by CO2 Asphyxiation. Total ACF ranged from 88 to 181.33 in rats fed C, LS and LNS, GS and GNS, YS and YNS. ACF reductions (%) compared to C were 68.56; 63.25 and 51.46 in rats fed LS at 10%, LNS at 10% and YNS at 10%, respectively. Glutathione content, Glutathione-S-transferase and Catalase activities were significantly higher (p<0.05) in rats fed treatment diets compared to C. Findings from this study indicate that sprouted and non sprouted green split and yellow peas and lentils reduced AOM-induced aberrant crypt foci in F344 male rats with the greatest reduction in rats fed Lentil sprouted (10%). Selected legumes appear to have beneficial potential in reducing colon cancer.
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 RELATED ARTICLES:
  •    Protective Effects of Rice Bran on Chemically Induced Colon Tumorigenesis may be Due to Synergistic/Additive Properties of Bioactive Components
  •    Effects of Processed Peaches (Prunus persica) in Reducing Azoxymethane (AOM) Induced Aberrant Crypt Foci (ACF) in Fisher 344 Male Rats
How to cite this article:

K. Busambwa, R.L. Miller-Cebert, L. Aboagye, L. Dalrymple, J. Boateng, L. Shackelford, L.T. Walker and M. Verghese, 2014. Inhibitory Effect of Lentils, Green Split and Yellow Peas (Sprouted and Non-sprouted) on Azoxymethane-induced Aberrant Crypt Foci in Fisher 344 Male Rats. International Journal of Cancer Research, 10: 27-36.

DOI: 10.3923/ijcr.2014.27.36

URL: https://scialert.net/abstract/?doi=ijcr.2014.27.36

 
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