
	International Journal of Cancer Research
	Year: 2012 \| Volume: 8 \| Issue: 3 \| Page No.: 95-104 DOI: 10.3923/ijcr.2012.95.104

Selected Cruciferous Vegetables and their Effects on Azoxymethane (AOM) Induced Aberrant Crypt Foci

R.L. Miller-Cebert, J. Boateng, L. Shackelford, E. Cebert, L.T. Walker and M. Verghese

Abstract: Cruciferous vegetables contain naturally occurring substances that are beneficial to health. The purpose of this study was to investigate the effects of selected cruciferous vegetables (Collard Green (CG), cabbage (CB), turnip green (TG) and canola green (CN) on Azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF) on Fisher 344 male rats. Thirty-six rats were randomly assigned to 9 groups (n = 4). The control group was fed AIN-93G diet and the other eight groups were fed AIN-93G along with the selected vegetables at 5 and 10%. The rats were administered subcutaneous injections of AOM at 7 and 8 weeks of age at 16 mg kg^-1 body weight. At 17 weeks of age, rats were killed by CO₂ asphyxiation. Total ACF numbers in rats fed CB, TG, CG and CN at 5% were 55, 41, 47 and 59, while at the 10% level, ACF numbers were 54, 63, 54 and 46, respectively. Total ACF in rats fed 5 and 10% cruciferous vegetables were significantly (p<0.05) lower (41-63) than rats fed the control diet (151). Findings indicate that cruciferous vegetables, including canola reduced the incidence of ACF and could potentially be used as a dietary chemopreventive agent against colon cancer.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Canola and Mustard Seeds/Sprouts Reduce the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colon Cancer in Fisher 344 Male Rats

•	Inhibitory Effects of Feeding Selected Levels of Peanuts on Azoxymethane-Induced Aberrant Crypt Foci in Male Fisher 344 Rats

•	Alterations in Plasma Lipid Peroxidation and Erythrocyte Superoxide Dismutase and Glutathione Peroxidase Enzyme Activities During Storage of Blood

•	Feeding Almonds and Pecans Reduced Development of Azoxymethane Induced Precancerous Lesions

How to cite this article:

R.L. Miller-Cebert, J. Boateng, L. Shackelford, E. Cebert, L.T. Walker and M. Verghese, 2012. Selected Cruciferous Vegetables and their Effects on Azoxymethane (AOM) Induced Aberrant Crypt Foci. International Journal of Cancer Research, 8: 95-104.

DOI: 10.3923/ijcr.2012.95.104

URL: https://scialert.net/abstract/?doi=ijcr.2012.95.104

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		FSTA
		SCIMAGO

Science Alert