Abstract:
Cruciferous vegetables contain naturally occurring substances that are beneficial to health. The purpose of this study was to investigate the effects of selected cruciferous vegetables (Collard Green (CG), cabbage (CB), turnip green (TG) and canola green (CN) on Azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF) on Fisher 344 male rats. Thirty-six rats were randomly assigned to 9 groups (n = 4). The control group was fed AIN-93G diet and the other eight groups were fed AIN-93G along with the selected vegetables at 5 and 10%. The rats were administered subcutaneous injections of AOM at 7 and 8 weeks of age at 16 mg kg-1 body weight. At 17 weeks of age, rats were killed by CO2 asphyxiation. Total ACF numbers in rats fed CB, TG, CG and CN at 5% were 55, 41, 47 and 59, while at the 10% level, ACF numbers were 54, 63, 54 and 46, respectively. Total ACF in rats fed 5 and 10% cruciferous vegetables were significantly (p<0.05) lower (41-63) than rats fed the control diet (151). Findings indicate that cruciferous vegetables, including canola reduced the incidence of ACF and could potentially be used as a dietary chemopreventive agent against colon cancer.
R.L. Miller-Cebert, J. Boateng, L. Shackelford, E. Cebert, L.T. Walker and M. Verghese, 2012. Selected Cruciferous Vegetables and their Effects on Azoxymethane (AOM) Induced Aberrant Crypt Foci. International Journal of Cancer Research, 8: 95-104.
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