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International Journal of Cancer Research
  Year: 2012 | Volume: 8 | Issue: 1 | Page No.: 1-14
DOI: 10.3923/ijcr.2012.1.14
Effects of Processed Peaches (Prunus persica) in Reducing Azoxymethane (AOM) Induced Aberrant Crypt Foci (ACF) in Fisher 344 Male Rats
B. Kanda, J. Boateng, L. Shackelford, S. Appiah, K. Campbell L. T. Walker and M. Verghese

Abstract:
Peach is an important fruit consumed worldwide. This study was conducted to investigate the effects of processed peaches (dried, frozen and juice) on Azoxymethane-induced (AOM) Aberrant Crypt Foci (ACF) in Fisher 344 male rats, their effect on selected hepatic enzyme activities and to determine the effect of processing (Blanching+Freezing, Blanching+Freeze drying) on total phenolic content and antioxidant potential (DPPH and FRAP). Rats were fed AIN93G as control (CON), treatment diets containing 2 and 4% peaches, and pasteurized juice (PJ) (2 and 4%). Rats received AOM injections s/c at 16 mg kg-1 b wt. during the 7th and 8th wk of age and killed by CO2 asphyxiation at 17 weeks of age. ACF incidence was higher in rats fed CON compared to treatment diets. Rats fed PJ had the lowest ACF (100 and 59 for 2 and 4%) compared to the treatment groups. Blanching (STB+BWB) influenced the incidence of ACF with STB having lower ACF numbers compared to BWB. GST, SOD and CAT (mmol/mg) activities, (9.56-1.43, 1.98-0.49 and 0.53-0.33), respectively were higher in rats fed treatment diets, compared to CON. Total phenolics, ranged from 98.09-120.38, 111.05-120.19, 104.76-122.09 (mg/GAE/g fwb) in FU, FRB and FDB peaches, respectively. FRAP (μg g-1) in FU, FRB and FDB peaches ranged from 0.028-0.042 while (%) DPPH (T30) ranged from 21.588-73.449. Results indicate processing of fruits may impact its role in chemoprevention, total phenolics and antioxidant activity, since fruits are highly perishable; optimum technique is required to minimize losses during and after processing.
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 RELATED ARTICLES:
  •    Inhibitory Effect of Lentils, Green Split and Yellow Peas (Sprouted and Non-sprouted) on Azoxymethane-induced Aberrant Crypt Foci in Fisher 344 Male Rats
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How to cite this article:

B. Kanda, J. Boateng, L. Shackelford, S. Appiah, K. Campbell L. T. Walker and M. Verghese, 2012. Effects of Processed Peaches (Prunus persica) in Reducing Azoxymethane (AOM) Induced Aberrant Crypt Foci (ACF) in Fisher 344 Male Rats. International Journal of Cancer Research, 8: 1-14.

DOI: 10.3923/ijcr.2012.1.14

URL: https://scialert.net/abstract/?doi=ijcr.2012.1.14

 
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